Kv1.3 Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.3/KCNA3 sub-subfamily. Note: This description may include information from UniProtKB.
Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of human Ortholog: 1p13.3
Cellular Component:  axon; calyx of Held; glutamatergic synapse; membrane; membrane raft; plasma membrane; postsynaptic membrane; presynaptic membrane; voltage-gated potassium channel complex
Molecular Function:  delayed rectifier potassium channel activity; outward rectifier potassium channel activity; protein binding; voltage-gated ion channel activity; voltage-gated potassium channel activity
Biological Process:  corpus callosum development; optic nerve development; potassium ion transmembrane transport; potassium ion transport; protein homooligomerization; regulation of ion transmembrane transport
Reference #:  P22001 (UniProtKB)
Alt. Names/Synonyms: HGK5; HLK3; HPCN3; HUKIII; KCNA3; KV1.3; MK3; PCN3; potassium channel 3; potassium channel, voltage gated shaker related subfamily A, member 3; Potassium voltage-gated channel subfamily A member 3; potassium voltage-gated channel, shaker-related subfamily, member 3; type n potassium channel; Voltage-gated K(+) channel HuKIII; voltage-gated potassium channel protein Kv1.3; Voltage-gated potassium channel subunit Kv1.3
Gene Symbols: KCNA3
Molecular weight: 63,842 Da
Basal Isoelectric point: 5.61  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene