TP1 Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction. Belongs to the nuclear transition protein 1 family. Expressed by spermatids (at protein level). Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of human Ortholog: 2q35
Cellular Component:  male germ cell nucleus; nucleosome; nucleus
Molecular Function:  DNA binding; protein binding
Biological Process:  chromatin remodeling; flagellated sperm motility; heterochromatin formation; negative regulation of DNA-templated transcription; nucleosome disassembly; positive regulation of protein processing; sexual reproduction; single strand break repair; sperm DNA condensation; sperm DNA decondensation; spermatid development; spermatid nucleus differentiation; spermatid nucleus elongation
Reference #:  P09430 (UniProtKB)
Alt. Names/Synonyms: Spermatid nuclear transition protein 1; STP-1; STP1; TNP1; TP-1; TP1; transition protein 1; transition protein 1 (during histone to protamine replacement)
Gene Symbols: TNP1
Molecular weight: 6,424 Da
Basal Isoelectric point: 12.09  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene