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TP1
Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction. Belongs to the nuclear transition protein 1 family. Expressed by spermatids (at protein level). Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding |
| Chromosomal Location of Human Ortholog: 2q35 |
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Cellular Component:
nuclear nucleosome; nucleosome; nucleus
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Molecular Function:
DNA binding; protein binding
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Biological Process:
chromatin remodeling; chromatin silencing; fertilization, exchange of chromosomal proteins; flagellated sperm motility; multicellular organism development; negative regulation of transcription, DNA-templated; nucleosome disassembly; positive regulation of protein processing; sexual reproduction; single strand break repair; spermatid development; spermatid nucleus differentiation; spermatid nucleus elongation; spermatogenesis, exchange of chromosomal proteins
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Reference #:
P09430
(UniProtKB)
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Alt. Names/Synonyms: Spermatid nuclear transition protein 1; STP-1; STP1; TNP1; TP-1; TP1; transition protein 1 (during histone to protamine replacement)
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Gene Symbols: TNP1
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Molecular weight:
6,424 Da
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Basal Isoelectric point:
12.09
Predict pI for various phosphorylation states
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