|
EIF4B
Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: RNA-binding; Translation; Translation initiation |
| Chromosomal Location of mouse Ortholog: 15|15 F2 |
|
Cellular Component:
cytosol; dendrite; neuronal cell body
|
|
Molecular Function:
nucleic acid binding; RNA binding; translation initiation factor activity
|
|
Biological Process:
translation; translational initiation
|
|
Reference #:
Q8BGD9
(UniProtKB)
|
|
Alt. Names/Synonyms: 2310046H11Rik; AL024095; C85189; eIF-4B; Eif4a2; Eif4b; Eukaryotic translation initiation factor 4B; IF4B
|
|
Gene Symbols: Eif4b
|
|
Molecular weight:
68,840 Da
|
|
Basal Isoelectric point:
5.47
Predict pI for various phosphorylation states
|
|
CST Pathways:
Growth And Differentiation Control by MAPKs
|
Translation: eIF4E and p70S6K
|
Translational Control
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|
