IL7R Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP). Belongs to the type I cytokine receptor family. Type 4 subfamily. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, cytokine
Chromosomal Location of Human Ortholog: 5p13.2
Cellular Component:  clathrin-coated vesicle membrane; external side of plasma membrane; extracellular region; integral component of membrane; plasma membrane
Molecular Function:  antigen binding; cytokine receptor activity; interleukin-7 receptor activity; protein binding
Biological Process:  B cell proliferation; cell morphogenesis; cell surface receptor signaling pathway; homeostasis of number of cells; immune response; immunoglobulin production; interleukin-7-mediated signaling pathway; lymph node development; membrane organization; negative regulation of T cell apoptotic process; negative regulation of T cell mediated cytotoxicity; positive regulation of cell proliferation; positive regulation of gene expression; positive regulation of STAT cascade; positive regulation of T cell differentiation in thymus; regulation of cell size; regulation of DNA recombination; signal transduction; T cell differentiation
Disease: Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-negative, B Cell-positive, Nk Cell-positive
Reference #:  P16871 (UniProtKB)
Alt. Names/Synonyms: CD127; CD127 antigen; CDw127; IL-7 receptor subunit alpha; IL-7R subunit alpha; IL-7R-alpha; IL-7RA; IL7R; IL7RA; ILRA; interleukin 7 receptor; interleukin 7 receptor alpha chain; interleukin 7 receptor isoform H5-6; Interleukin-7 receptor subunit alpha
Gene Symbols: IL7R
Molecular weight: 51,579 Da
Basal Isoelectric point: 5.27  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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