VDR Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells. Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR. The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes. Plays a central role in calcium homeostasis. Belongs to the nuclear hormone receptor family. NR1 subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nuclear receptor; Transcription factor
Chromosomal Location of Human Ortholog: 7q36
Cellular Component:  cytosol; dense fibrillar component; euchromatin; heterochromatin; intracellular membrane-bounded organelle; nuclear heterochromatin; nuclear matrix; nucleoplasm; nucleus; perinuclear region of cytoplasm; receptor complex; RNA polymerase II transcription factor complex; T-tubule
Molecular Function:  calcitriol binding; DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; lithocholic acid binding; lithocholic acid receptor activity; nuclear receptor activity; nuclear receptor transcription coactivator activity; protein binding; retinoid X receptor binding; RNA polymerase II regulatory region sequence-specific DNA binding; sequence-specific DNA binding; signaling receptor activity; steroid hormone receptor activity; transcription factor binding; transcription regulatory region sequence-specific DNA binding; vitamin D binding; vitamin D response element binding; zinc ion binding
Biological Process:  aging; animal organ morphogenesis; apoptotic signaling pathway; bile acid signaling pathway; calcium ion transport; cell differentiation; cell morphogenesis; cellular calcium ion homeostasis; cellular response to amyloid-beta; cellular response to vitamin D; decidualization; heart development; intestinal absorption; intracellular receptor signaling pathway; lactation; mammary gland branching involved in pregnancy; multicellular organism development; negative regulation of cell proliferation; negative regulation of keratinocyte proliferation; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; positive regulation of apoptotic process involved in mammary gland involution; positive regulation of gene expression; positive regulation of keratinocyte differentiation; positive regulation of transcription by RNA polymerase II; positive regulation of vitamin D 24-hydroxylase activity; regulation of calcidiol 1-monooxygenase activity; regulation of calcium ion transport; regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; response to calcium ion; response to estradiol; skeletal system development; steroid hormone mediated signaling pathway; vitamin D receptor signaling pathway
Reference #:  P13053 (UniProtKB)
Alt. Names/Synonyms: 1,25-dihydroxyvitamin D3 receptor; Nr1i1; Nuclear receptor subfamily 1 group I member 1; VDR; vitamin D (1,25- dihydroxyvitamin D3) receptor; vitamin D (1,25-dihydroxyvitamin D3) receptor; Vitamin D (125-dihydroxyvitamin D3) receptor; vitamin D receptor; Vitamin D3 receptor
Gene Symbols: Vdr
Molecular weight: 47,814 Da
Basal Isoelectric point: 5.88  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA