VDR Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells. Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR. The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes. Plays a central role in calcium homeostasis. Belongs to the nuclear hormone receptor family. NR1 subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nuclear receptor; Transcription factor
Chromosomal Location of rat Ortholog: 7q36
Cellular Component:  caveola; cytosol; dense fibrillar component; euchromatin; heterochromatin; nuclear matrix; nucleoplasm; nucleus; perinuclear region of cytoplasm; receptor complex; RNA polymerase II transcription regulator complex; T-tubule
Molecular Function:  calcitriol binding; DNA binding; DNA-binding transcription factor activity; lithocholic acid binding; lithocholic acid receptor activity; nuclear receptor activity; nuclear retinoid X receptor binding; nucleic acid binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding; small molecule binding; vitamin D binding; vitamin D response element binding; zinc ion binding
Biological Process:  animal organ morphogenesis; apoptotic process involved in mammary gland involution; apoptotic signaling pathway; bile acid signaling pathway; calcium ion transport; cell differentiation; cell morphogenesis; cellular response to amyloid-beta; cellular response to vitamin D; decidualization; heart development; intestinal absorption; intracellular calcium ion homeostasis; lactation; mammary gland branching involved in pregnancy; mRNA transcription by RNA polymerase II; multicellular organism development; negative regulation of bone trabecula formation; negative regulation of cell population proliferation; negative regulation of DNA-templated transcription; negative regulation of keratinocyte proliferation; negative regulation of ossification; negative regulation of transcription by RNA polymerase II; phosphate ion transmembrane transport; positive regulation of apoptotic process involved in mammary gland involution; positive regulation of gene expression; positive regulation of keratinocyte differentiation; positive regulation of parathyroid hormone secretion; positive regulation of transcription by RNA polymerase II; positive regulation of vitamin D 24-hydroxylase activity; positive regulation of vitamin D receptor signaling pathway; regulation of calcidiol 1-monooxygenase activity; regulation of calcium ion transport; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; response to aldosterone; response to bile acid; response to calcium ion; response to estradiol; skeletal system development; vitamin D receptor signaling pathway
Reference #:  P13053 (UniProtKB)
Alt. Names/Synonyms: 1,25-dihydroxyvitamin D3 receptor; Nr1i1; Nuclear receptor subfamily 1 group I member 1; VDR; vitamin D (1,25- dihydroxyvitamin D3) receptor; vitamin D (1,25-dihydroxyvitamin D3) receptor; Vitamin D (125-dihydroxyvitamin D3) receptor; vitamin D receptor; Vitamin D3 receptor
Gene Symbols: Vdr
Molecular weight: 47,814 Da
Basal Isoelectric point: 5.88  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA