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ODC
Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. Belongs to the Orn/Lys/Arg decarboxylase class-II family. Note: This description may include information from UniProtKB.
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| Protein type: Amino Acid Metabolism - arginine and proline; Cell cycle regulation; EC 4.1.1.17; Lyase; Other Amino Acids Metabolism - glutathione |
| Chromosomal Location of mouse Ortholog: 12 A1.1|12 8.11 cM |
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Cellular Component:
cytoplasm; cytosol; perinuclear region of cytoplasm
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Molecular Function:
carboxy-lyase activity; catalytic activity; lyase activity; ornithine decarboxylase activity; protein homodimerization activity
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Biological Process:
cell population proliferation; kidney development; polyamine biosynthetic process; polyamine metabolic process; positive regulation of cell population proliferation; putrescine biosynthetic process; putrescine biosynthetic process from ornithine; regulation of protein catabolic process
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Reference #:
P00860
(UniProtKB)
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Alt. Names/Synonyms: DCOR; MGC103389; ODC; Odc1; Ornithine decarboxylase; ornithine decarboxylase, structural 1
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Gene Symbols: Odc1
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Molecular weight:
51,177 Da
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Basal Isoelectric point:
5.26
Predict pI for various phosphorylation states
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