NIPP-1 Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation. Isoform Gamma is a site-specific single-strand endoribonuclease that cleaves single strand RNA 3' to purines and pyrimidines in A+U-rich regions. It generates 5'-phosphate termini at the site of cleavage. This isoform does not inhibit PP-1. May be implicated in mRNA splicing. Ubiquitously expressed, with highest levels in heart and skeletal muscle, followed by brain, placenta, lung, liver and pancreas. Less abundant in kidney. The concentration and ratio between isoforms is cell-type dependent. Isoform Alpha ( 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.4.-; Inhibitor; Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit; Ribonuclease
Cellular Component:  spliceosomal complex
Molecular Function:  DNA binding
Biological Process:  mRNA processing; negative regulation of phosphoprotein phosphatase activity; RNA splicing
Reference #:  Q28147 (UniProtKB)
Alt. Names/Synonyms: NIPP-1; NIPP1; Nuclear inhibitor of protein phosphatase 1; Nuclear inhibitor of protein phosphatase-1; PP1R8; PPP1R8; PPR8; Protein phosphatase 1, regulatory inhibitor subunit 8
Gene Symbols: PPP1R8
Molecular weight: 38,521 Da
Basal Isoelectric point: 6.87  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene