GATA1 Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS. Erythrocytes. 3 alternative splicing and alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: Xp11.23
Cellular Component:  nucleoplasm; nucleus; protein-DNA complex; transcription factor complex; transcriptional repressor complex
Molecular Function:  C2H2 zinc finger domain binding; chromatin DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; p53 binding; protein binding; RNA polymerase II distal enhancer sequence-specific DNA binding; RNA polymerase II proximal promoter sequence-specific DNA binding; RNA polymerase II regulatory region sequence-specific DNA binding; RNA polymerase II transcription factor binding; sequence-specific DNA binding; transcription regulatory region sequence-specific DNA binding; zinc ion binding
Biological Process:  basophil differentiation; blood coagulation; cell-cell signaling; cellular response to thyroid hormone stimulus; dendritic cell differentiation; embryonic hemopoiesis; eosinophil differentiation; eosinophil fate commitment; erythrocyte development; erythrocyte differentiation; homeostasis of number of cells within a tissue; in utero embryonic development; male gonad development; megakaryocyte differentiation; negative regulation of apoptotic process; negative regulation of bone mineralization; negative regulation of cell proliferation; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of transcription by RNA polymerase II; negative regulation of transcription regulatory region DNA binding; platelet aggregation; platelet formation; positive regulation of erythrocyte differentiation; positive regulation of osteoblast proliferation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; regulation of definitive erythrocyte differentiation; regulation of glycoprotein biosynthetic process; regulation of hematopoietic stem cell differentiation; regulation of megakaryocyte differentiation; regulation of primitive erythrocyte differentiation; transcription by RNA polymerase II; transcriptional activation by promoter-enhancer looping
Disease: Anemia, X-linked, With Or Without Neutropenia And/or Platelet Abnormalities; Down Syndrome; Thrombocytopenia With Beta-thalassemia, X-linked; Thrombocytopenia, X-linked, With Or Without Dyserythropoietic Anemia
Reference #:  P15976 (UniProtKB)
Alt. Names/Synonyms: ERYF1; Erythroid transcription factor; erythroid transcription factor 1; GATA binding protein 1; GATA binding protein 1 (globin transcription factor 1); GATA-1; GATA-binding factor 1; GATA1; GF-1; GF1; globin transcription factor 1; NF-E1; NF-E1 DNA-binding protein; NFE1; nuclear factor, erythroid 1; transcription factor GATA1; XLANP; XLTDA; XLTT
Gene Symbols: GATA1
Molecular weight: 42,751 Da
Basal Isoelectric point: 9.03  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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