IL1A Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. Belongs to the IL-1 family. Note: This description may include information from UniProtKB.
Protein type: Cytokine; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 2 F1|2 62.9 cM
Cellular Component:  cell surface; cytoplasm; cytosol; extracellular region; extracellular space; plasma membrane
Molecular Function:  copper ion binding; cytokine activity; interleukin-1 receptor binding
Biological Process:  cellular response to heat; connective tissue replacement during inflammatory response; cytokine-mediated signaling pathway; fever; germ cell programmed cell death; immune response; inflammatory response; keratinization; negative regulation of cell proliferation; negative regulation of establishment of Sertoli cell barrier; positive regulation of angiogenesis; positive regulation of cell division; positive regulation of cytokine secretion; positive regulation of ERK1 and ERK2 cascade; positive regulation of gene expression; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of interleukin-2 biosynthetic process; positive regulation of interleukin-6 production; positive regulation of JNK cascade; positive regulation of mitotic nuclear division; positive regulation of monocyte chemotactic protein-1 production; positive regulation of neutrophil extravasation; positive regulation of neutrophil migration; positive regulation of prostaglandin secretion; positive regulation of protein secretion; positive regulation of steroid biosynthetic process; positive regulation of stress-activated MAPK cascade; positive regulation of transcription from RNA polymerase II promoter; positive regulation of vascular endothelial growth factor production; regulation of actin cytoskeleton organization; regulation of sensory perception of pain; response to copper ion
Reference #:  P01582 (UniProtKB)
Alt. Names/Synonyms: IL-1 alpha; Il-1a; Il1a; interleukin 1 alpha; Interleukin-1 alpha; OTTMUSP00000016430
Gene Symbols: Il1a
Molecular weight: 31,023 Da
Basal Isoelectric point: 5.12  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene