ITGA6 iso2 Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling. ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling. Belongs to the integrin alpha chain family. Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoforms containing segment X1 are ubiquitously expressed. Isoforms containing segment X1X2 are expressed in heart, kidney, placenta, colon, duodenum, myoblasts and myotubes, and in a limited number of cell lines; they are always coexpressed with the ubiquitous isoform containing segment X1. In some tissues (e.g. Salivary gland), isoforms containing cytoplasmic segment A and isoforms containing segment B are detected while in others, only isoforms containing one cytoplasmic segment are found (segment A in epidermis and segment B in kidney). 8 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.
Chromosomal Location of Human Ortholog: 2q31.1
Cellular Component:  basal plasma membrane; basement membrane; cell surface; cell-cell adherens junction; external side of plasma membrane; filopodium; hemidesmosome; integrin alpha6-beta4 complex; plasma membrane
Molecular Function:  insulin-like growth factor I binding; laminin binding; metal ion binding; neuregulin binding; protein binding; protein-containing complex binding
Biological Process:  amelogenesis; brown fat cell differentiation; cell-cell adhesion; cell-matrix adhesion; cell-substrate adhesion; cell-substrate junction assembly; cellular response to extracellular stimulus; cellular response to organic cyclic compound; digestive tract development; ectodermal cell differentiation; extracellular matrix organization; filopodium assembly; hemidesmosome assembly; integrin-mediated signaling pathway; leukocyte migration; nail development; negative regulation of extrinsic apoptotic signaling pathway; positive regulation of apoptotic process; positive regulation of cell migration; positive regulation of cell-cell adhesion; positive regulation of cell-substrate adhesion; positive regulation of GTPase activity; positive regulation of neuron projection development; positive regulation of phosphorylation; positive regulation of transcription by RNA polymerase II; renal system development; skin development
Disease: Epidermolysis Bullosa Junctionalis With Pyloric Atresia
Reference #:  P23229-2 (UniProtKB)
Alt. Names/Synonyms: Alpha6p; CD49 antigen-like family member F; CD49f; DKFZp686J01244; FLJ18737; Integrin alpha-6; Integrin alpha-6 heavy chain; Integrin alpha-6 light chain; integrin alpha6B; integrin subunit alpha 6; integrin, alpha 6; ITA6; ITGA6; ITGA6 iso2; ITGA6B; Processed integrin alpha-6; VLA-6
Gene Symbols: ITGA6
Molecular weight: 119,476 Da
Basal Isoelectric point: 6.35  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  PI3K/Akt Signaling
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ITGA6 iso2

Protein Structure Not Found.

Cross-references to other databases:  cBioPortal  |  Wikipedia  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein