EPB41 Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of mouse Ortholog: 4 D2.3|4 64.54 cM
Cellular Component:  actin cytoskeleton; basolateral plasma membrane; cell cortex; cell junction; cortical cytoskeleton; cytoplasm; cytoplasmic side of plasma membrane; cytoskeleton; cytosol; intercellular bridge; membrane; mitotic spindle; nuclear body; nucleus; plasma membrane; protein-containing complex
Molecular Function:  1-phosphatidylinositol binding; actin binding; calmodulin binding; cytoskeletal protein binding; phosphoprotein binding; protein binding; spectrin binding; structural constituent of cytoskeleton; structural molecule activity
Biological Process:  actin cytoskeleton organization; actomyosin structure organization; cell cycle; cell division; cortical actin cytoskeleton organization; positive regulation of protein binding; positive regulation of protein localization to cell cortex; protein-containing complex assembly; regulation of calcium ion transport; regulation of cell shape; regulation of intestinal absorption
Reference #:  P48193 (UniProtKB)
Alt. Names/Synonyms: 4.1; 4.1R; 41; AI415518; Band 4.1; D4Ertd442; D4Ertd442e; Elp; Elp-1; Elp1; Epb4.; Epb4.1; Epb41; erythrocyte membrane protein band 4.1; erythrocyte protein band 4.1; Kiaa4056; mKIAA4056; OTTMUSP00000010859; P4.1; Protein 4.1; Protein 4.1R
Gene Symbols: Epb41
Molecular weight: 95,911 Da
Basal Isoelectric point: 5.44  Predict pI for various phosphorylation states
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EPB41

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein