RUFY1 Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking. Broadly expressed, with highest levels in lung, testis, kidney and brain. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 5q35.3
Cellular Component:  cytosol; early endosome membrane; endosome; intracellular membrane-bounded organelle; nuclear speck; nucleus
Molecular Function:  lipid binding; metal ion binding; protein binding; SH2 domain binding; SH3 domain binding
Biological Process:  endocytosis; phosphatidylinositol biosynthetic process; regulation of endocytosis; small GTPase mediated signal transduction
Reference #:  Q96T51 (UniProtKB)
Alt. Names/Synonyms: FLJ22251; FYVE-finger protein EIP1; La-binding protein 1; Rab4-interacting protein; RABIP4; RUFY1; RUN and FYVE domain containing 1; RUN and FYVE domain-containing 1; RUN and FYVE domain-containing protein 1; ZFYVE12; Zinc finger FYVE domain-containing protein 12
Gene Symbols: RUFY1
Molecular weight: 79,818 Da
Basal Isoelectric point: 5.54  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein