TNF-R1 Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, cytokine
Chromosomal Location of human Ortholog: 12p13.31
Cellular Component:  cell surface; extracellular region; extracellular space; Golgi membrane; integral component of plasma membrane; membrane; membrane raft; plasma membrane; receptor complex; tumor necrosis factor receptor superfamily complex
Molecular Function:  protein binding; tumor necrosis factor binding; tumor necrosis factor-activated receptor activity
Biological Process:  aortic valve development; cellular response to mechanical stimulus; cytokine-mediated signaling pathway; death-inducing signaling complex assembly; defense response to bacterium; extrinsic apoptotic signaling pathway via death domain receptors; I-kappaB kinase/NF-kappaB signaling; inflammatory response; intrinsic apoptotic signaling pathway in response to DNA damage; negative regulation of cardiac muscle hypertrophy; negative regulation of extracellular matrix constituent secretion; negative regulation of inflammatory response; positive regulation of apoptotic process involved in morphogenesis; positive regulation of ceramide biosynthetic process; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of inflammatory response; positive regulation of transcription by RNA polymerase II; positive regulation of tyrosine phosphorylation of STAT protein; prostaglandin metabolic process; protein localization to plasma membrane; pulmonary valve development; regulation of establishment of endothelial barrier; regulation of tumor necrosis factor-mediated signaling pathway; tumor necrosis factor-mediated signaling pathway; viral process
Disease: Multiple Sclerosis, Susceptibility To, 5; Periodic Fever, Familial, Autosomal Dominant
Reference #:  P19438 (UniProtKB)
Alt. Names/Synonyms: CD120a; FPF; MGC19588; p55; p55-R; p60; TBP1; TBPI; TNF receptor superfamily member 1A; TNF-R; TNF-R-I; TNF-R1; TNF-R55; TNF-RI; TNFAR; TNFR-I; TNFR1; TNFR55; TNFR60; TNFRSF1A; TNR1A; tumor necrosis factor binding protein 1; Tumor necrosis factor receptor 1; tumor necrosis factor receptor 1A isoform beta; Tumor necrosis factor receptor superfamily member 1A; Tumor necrosis factor receptor superfamily member 1A, membrane form; tumor necrosis factor receptor superfamily, member 1A; tumor necrosis factor receptor type 1; Tumor necrosis factor receptor type I; tumor necrosis factor-alpha receptor; Tumor necrosis factor-binding protein 1
Gene Symbols: TNFRSF1A
Molecular weight: 50,495 Da
Basal Isoelectric point: 6.23  Predict pI for various phosphorylation states
CST Pathways:  Death Receptor Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  NF-kB Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB