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TNF-R1
Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Receptor, cytokine |
| Chromosomal Location of human Ortholog: 12p13.31 |
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Cellular Component:
cell surface; extracellular region; extracellular space; Golgi membrane; membrane; membrane raft; plasma membrane; receptor complex; tumor necrosis factor receptor superfamily complex
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Molecular Function:
protein binding; tumor necrosis factor binding; tumor necrosis factor receptor activity
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Biological Process:
aortic valve development; cellular response to mechanical stimulus; cytokine-mediated signaling pathway; defense response to bacterium; extrinsic apoptotic signaling pathway via death domain receptors; inflammatory response; intrinsic apoptotic signaling pathway in response to DNA damage; negative regulation of cardiac muscle hypertrophy; negative regulation of extracellular matrix constituent secretion; negative regulation of inflammatory response; positive regulation of apoptotic process involved in morphogenesis; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of inflammatory response; positive regulation of transcription by RNA polymerase II; positive regulation of tyrosine phosphorylation of STAT protein; prostaglandin metabolic process; protein localization to plasma membrane; pulmonary valve development; regulation of establishment of endothelial barrier; regulation of tumor necrosis factor-mediated signaling pathway; transcription by RNA polymerase II; tumor necrosis factor-mediated signaling pathway
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Disease: Multiple Sclerosis, Susceptibility To, 5; Periodic Fever, Familial, Autosomal Dominant
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Reference #:
P19438
(UniProtKB)
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Alt. Names/Synonyms: CD120a; FPF; MGC19588; p55; p55-R; p60; TBP1; TBPI; TNF receptor superfamily member 1A; TNF-R; TNF-R-I; TNF-R1; TNF-R55; TNF-RI; TNFAR; TNFR-I; TNFR1; TNFR55; TNFR60; TNFRSF1A; TNR1A; tumor necrosis factor binding protein 1; Tumor necrosis factor receptor 1; tumor necrosis factor receptor 1A isoform beta; Tumor necrosis factor receptor superfamily member 1A; Tumor necrosis factor receptor superfamily member 1A, membrane form; tumor necrosis factor receptor superfamily, member 1A; tumor necrosis factor receptor type 1; Tumor necrosis factor receptor type I; tumor necrosis factor-alpha receptor; Tumor necrosis factor-binding protein 1
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Gene Symbols: TNFRSF1A
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Molecular weight:
50,495 Da
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Basal Isoelectric point:
6.23
Predict pI for various phosphorylation states
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CST Pathways:
Death Receptor Signaling
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Inhibition of Apoptosis
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Insulin Receptor Signaling
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NF-kB Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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