Stargazin Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. Brain. Note: This description may include information from UniProtKB.
Protein type: Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 22q12.3
Cellular Component:  AMPA glutamate receptor complex; cell junction; cell surface; cerebellar mossy fiber; cytosol; endocytic vesicle membrane; glutamatergic synapse; hippocampal mossy fiber to CA3 synapse; integral component of postsynaptic density membrane; plasma membrane; Schaffer collateral - CA1 synapse; somatodendritic compartment; voltage-gated calcium channel complex
Molecular Function:  ionotropic glutamate receptor binding; protein binding
Biological Process:  calcium ion transmembrane transport; cardiac conduction; eye blink reflex; membrane depolarization; membrane hyperpolarization; neuromuscular junction development; positive regulation of AMPA receptor activity; positive regulation of protein localization to basolateral plasma membrane; protein targeting to membrane; regulation of AMPA receptor activity; response to calcium ion
Disease: Mental Retardation, Autosomal Dominant 10
Reference #:  Q9Y698 (UniProtKB)
Alt. Names/Synonyms: CACNG2; calcium channel, voltage-dependent, gamma subunit 2; calcium voltage-gated channel auxiliary subunit gamma 2; CCG2; MGC138502; MGC138504; MRD10; Neuronal voltage-gated calcium channel gamma-2 subunit; stargazin; TARP gamma-2; Transmembrane AMPAR regulatory protein gamma-2; Voltage-dependent calcium channel gamma-2 subunit
Gene Symbols: CACNG2
Molecular weight: 35,966 Da
Basal Isoelectric point: 9.13  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Stargazin

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB