CD46 Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. (Microbial infection) A number of viral and bacterial pathogens seem to bind MCP in order to exploit its immune regulation property and directly induce an immunosuppressive phenotype in T-cells. (Microbial infection) Acts as a receptor for Adenovirus subgroup B2 and Ad3. (Microbial infection) Acts as a receptor for cultured Measles virus. (Microbial infection) Acts as a receptor for Herpesvirus 6/HHV-6. (Microbial infection) May act as a receptor for pathogenic bacteria Neisseria and Streptococcus pyogenes. Expressed by all cells except erythrocytes. 16 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell surface; Membrane protein, integral; Receptor, misc.
Chromosomal Location of human Ortholog: 1q32.2
Cellular Component:  cell surface; inner acrosomal membrane; integral component of plasma membrane; plasma membrane
Molecular Function:  cadherin binding; protein binding; signaling receptor activity; virus receptor activity
Biological Process:  adaptive immune response; complement activation, classical pathway; innate immune response; interleukin-10 production; negative regulation of gene expression; positive regulation of gene expression; positive regulation of interleukin-10 production; positive regulation of memory T cell differentiation; positive regulation of regulatory T cell differentiation; positive regulation of T cell proliferation; positive regulation of transforming growth factor beta production; regulation of complement activation; regulation of Notch signaling pathway; sequestering of extracellular ligand from receptor; single fertilization; T cell mediated immunity; viral entry into host cell
Disease: Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 2
Reference #:  P15529 (UniProtKB)
Alt. Names/Synonyms: AHUS2; antigen identified by monoclonal antibody TRA-2-10; CD46; CD46 antigen, complement regulatory protein; CD46 molecule; CD46 molecule, complement regulatory protein; complement membrane cofactor protein; MCP; measles virus receptor; Membrane cofactor protein; membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen); MGC26544; MIC10; TLX; TRA2.10; trophoblast leucocyte common antigen; Trophoblast leukocyte common antigen; trophoblast-lymphocyte cross-reactive antigen
Gene Symbols: CD46
Molecular weight: 43,747 Da
Basal Isoelectric point: 6.34  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein