PTGIR Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase. Belongs to the G-protein coupled receptor 1 family. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of mouse Ortholog: 7 A2|7 9.15 cM
Cellular Component:  cytosol; integral component of membrane; membrane; plasma membrane
Molecular Function:  G protein-coupled receptor activity; prostacyclin receptor activity
Biological Process:  adenylate cyclase-activating G protein-coupled receptor signaling pathway; G protein-coupled receptor signaling pathway; inflammatory response; negative regulation of platelet-derived growth factor receptor signaling pathway; negative regulation of smooth muscle cell proliferation; positive regulation of cytosolic calcium ion concentration; response to lipopolysaccharide; signal transduction
Reference #:  P43252 (UniProtKB)
Alt. Names/Synonyms: IP; PGI receptor; PGI2; PGI2 receptor; PI2R; Prostacyclin receptor; prostaglandin I receptor (IP); Prostaglandin I2 receptor; Prostanoid IP receptor; Ptgir
Gene Symbols: Ptgir
Molecular weight: 44,463 Da
Basal Isoelectric point: 8.7  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene