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PTGIR
Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase. Belongs to the G-protein coupled receptor 1 family. Note: This description may include information from UniProtKB.
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| Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR |
| Chromosomal Location of Human Ortholog: 7 A2|7 9.15 cM |
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Cellular Component:
cytosol; integral component of membrane; membrane; plasma membrane
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Molecular Function:
G protein-coupled receptor activity; prostacyclin receptor activity
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Biological Process:
adenylate cyclase-activating G protein-coupled receptor signaling pathway; G protein-coupled receptor signaling pathway; inflammatory response; negative regulation of platelet-derived growth factor receptor signaling pathway; negative regulation of smooth muscle cell proliferation; positive regulation of cytosolic calcium ion concentration; response to lipopolysaccharide; signal transduction
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Reference #:
P43252
(UniProtKB)
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Alt. Names/Synonyms: IP; PGI receptor; PGI2 receptor; PI2R; Prostacyclin receptor; prostaglandin I receptor (IP); Prostaglandin I2 receptor; Prostanoid IP receptor; Ptgir
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Gene Symbols: Ptgir
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Molecular weight:
44,463 Da
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Basal Isoelectric point:
8.7
Predict pI for various phosphorylation states
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