ID2 Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Restricts the CLOCK and ARNTL/BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism. Highly expressed in early fetal tissues, including those of the central nervous system. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 12 A1.3|12 8.57 cM
Cellular Component:  chromatin; cytoplasm; cytosol; nucleus; protein-containing complex
Molecular Function:  DNA-binding transcription factor activity; ion channel binding; protein binding; protein dimerization activity; RNA polymerase II transcription factor binding; transcription factor binding
Biological Process:  adipose tissue development; adult locomotory behavior; bundle of His development; cell development; cell maturation; cell morphogenesis involved in neuron differentiation; cellular response to lithium ion; cellular senescence; circadian regulation of gene expression; circadian rhythm; embryonic digestive tract morphogenesis; endodermal digestive tract morphogenesis; entrainment of circadian clock; entrainment of circadian clock by photoperiod; enucleate erythrocyte differentiation; epithelial cell differentiation involved in mammary gland alveolus development; heart development; leukocyte differentiation; locomotor rhythm; lymph node development; mammary gland alveolus development; mammary gland epithelial cell proliferation; membranous septum morphogenesis; metanephros development; multicellular organism development; natural killer cell differentiation; negative regulation of B cell differentiation; negative regulation of DNA binding; negative regulation of DNA-binding transcription factor activity; negative regulation of gene expression; negative regulation of neural precursor cell proliferation; negative regulation of neuron differentiation; negative regulation of oligodendrocyte differentiation; negative regulation of osteoblast differentiation; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; neuron differentiation; neuron fate commitment; olfactory bulb development; oligodendrocyte development; Peyer's patch development; positive regulation of astrocyte differentiation; positive regulation of blood pressure; positive regulation of cell cycle; positive regulation of cell cycle arrest; positive regulation of cell proliferation; positive regulation of erythrocyte differentiation; positive regulation of fat cell differentiation; positive regulation of gene expression; positive regulation of macrophage differentiation; positive regulation of smooth muscle cell proliferation; positive regulation of transcription, DNA-templated; regulation of cell cycle; regulation of circadian rhythm; regulation of G1/S transition of mitotic cell cycle; regulation of lipid metabolic process; rhythmic process; thigmotaxis
Reference #:  P41136 (UniProtKB)
Alt. Names/Synonyms: AI255428; bHLHb26; C78922; DNA-binding protein inhibitor ID-2; Id-2; Id2; Idb2; inhibitor of differentiation 2; Inhibitor of DNA binding 2
Gene Symbols: Id2
Molecular weight: 14,959 Da
Basal Isoelectric point: 7.82  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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ID2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene