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ID2
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Restricts the CLOCK and ARNTL/BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism. Highly expressed in early fetal tissues, including those of the central nervous system. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Transcription, coactivator/corepressor |
| Chromosomal Location of human Ortholog: 2p25.1 |
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Cellular Component:
cytoplasm; cytosol; euchromatin; nucleoplasm; nucleus; protein-containing complex
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Molecular Function:
protein binding; protein dimerization activity; RNA polymerase II-specific DNA-binding transcription factor binding; transcription regulator activity; transcription regulator inhibitor activity; transmembrane transporter binding
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Biological Process:
bundle of His development; cell differentiation; cellular senescence; circadian regulation of gene expression; circadian rhythm; embryonic digestive tract morphogenesis; endodermal digestive tract morphogenesis; entrainment of circadian clock by photoperiod; enucleate erythrocyte differentiation; epithelial cell differentiation involved in mammary gland alveolus development; heart development; locomotor rhythm; mammary gland alveolus development; mammary gland epithelial cell proliferation; negative regulation of B cell differentiation; negative regulation of DNA-binding transcription factor activity; negative regulation of DNA-templated transcription; negative regulation of gene expression; negative regulation of muscle cell differentiation; negative regulation of transcription by RNA polymerase II; neuron fate commitment; olfactory bulb development; positive regulation of astrocyte differentiation; positive regulation of blood pressure; positive regulation of DNA-templated transcription; positive regulation of fat cell differentiation; positive regulation of gene expression; positive regulation of macrophage differentiation; positive regulation of smooth muscle cell proliferation; positive regulation of transcription involved in G1/S transition of mitotic cell cycle; regulation of circadian rhythm; regulation of G1/S transition of mitotic cell cycle; regulation of lipid metabolic process; regulation of neural precursor cell proliferation; regulation of neuron differentiation
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Reference #:
Q02363
(UniProtKB)
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Alt. Names/Synonyms: BHLHB26; cell growth-inhibiting gene 8; Class B basic helix-loop-helix protein 26; DNA-binding protein inhibitor ID-2; DNA-binding protein inhibitor ID2; GIG8; helix-loop-helix protein ID2; ID2; ID2A; ID2H; inhibitor of differentiation 2; Inhibitor of DNA binding 2; inhibitor of DNA binding 2, dominant negative helix-loop-helix protein; inhibitor of DNA binding 2, HLH protein; MGC26389
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Gene Symbols: ID2
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Molecular weight:
14,917 Da
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Basal Isoelectric point:
7.82
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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