SHC3 an adapter protein containing an SH2 and a PID domain. Couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons and the regulation of NMDA receptor function in the hippocampus. May modulate hippocampal synaptic plasticity underlying learning and memory. Interacts with the Trk receptors in a phosphotyrosine-dependent manner. Once activated, binds to GRB2. Interacts with activated EGF receptors. Mainly expressed in brain. Hardly detectable in other tissues, except in pancreas. Highly expressed in the cerebral cortex, frontal and temporal lobes, occipital pole, hippocampus, caudate nucleus and amygdala. Expressed at low level in the cerebellum, medulla and spinal cord. A switch from Shc1 to Shc3 occurs during maturation of neuronal precursors to postmitotic neurons. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 13 A5|13 26.12 cM
Cellular Component:  plasma membrane
Molecular Function:  phosphotyrosine residue binding; protein binding; receptor tyrosine kinase binding
Biological Process:  central nervous system development; intracellular signal transduction; learning or memory; signal transduction; synaptic transmission, glutamatergic
Reference #:  Q61120 (UniProtKB)
Alt. Names/Synonyms: MGC124163; N-Shc; Neuronal Shc; Nshc; Rai; SH2 domain protein C3; SHC-transforming protein 3; SHC-transforming protein C; Shc3; ShcC; src homology 2 domain-containing transforming protein C3; Src homology 2 domain-containing-transforming protein C3
Gene Symbols: Shc3
Molecular weight: 52,121 Da
Basal Isoelectric point: 6.87  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  Growth And Differentiation Control by MAPKs  |  IL6 Signaling  |  Insulin Receptor Signaling  |  SAPK/JNK Signaling Cascades  |  TGF-ß Signaling
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SHC3

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene