IFNGR1 Associates with IFNGR2 to form a receptor for the cytokine interferon gamma (IFNG). Ligand binding stimulates activation of the JAK/STAT signaling pathway. Plays an essential role in the IFN-gamma pathway that is required for the cellular response to infectious agents. Belongs to the type II cytokine receptor family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, cytokine
Chromosomal Location of Human Ortholog: 6q23.3
Cellular Component:  integral component of plasma membrane; plasma membrane
Molecular Function:  cytokine binding; interferon-gamma receptor activity; protein binding
Biological Process:  interferon-gamma-mediated signaling pathway; regulation of interferon-gamma-mediated signaling pathway; response to virus; signal transduction
Disease: Helicobacter Pylori Infection, Susceptibility To; Hepatitis B Virus, Susceptibility To; Immunodeficiency 27a; Immunodeficiency 27b; Mycobacterium Tuberculosis, Susceptibility To
Reference #:  P15260 (UniProtKB)
Alt. Names/Synonyms: antiviral protein, type 2; AVP, type 2; CD119; CD119 antigen; CDw119; FLJ45734; IFN-gamma receptor 1; IFN-gamma-R-alpha; IFN-gamma-R1; IFNGR; IFNGR1; IMD27A; IMD27B; immune interferon receptor 1; INGR1; Interferon gamma receptor 1; Interferon gamma receptor alpha-chain; interferon-gamma receptor alpha chain
Gene Symbols: IFNGR1
Molecular weight: 54,405 Da
Basal Isoelectric point: 4.83  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene