Vinculin Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell- surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. Exhibits self-association properties. Interacts with NRAP and SORBS1. Interacts with TLN1. Interacts with SYNM. Interacts with CTNNB1 and this interaction is necessary for its localization to the cell-cell junctions and for its function in regulating cell surface expression of E-cadherin. Metavinculin is muscle-specific. Belongs to the vinculin/alpha-catenin family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 10q22.2
Cellular Component:  adherens junction; cell-cell adherens junction; cell-cell junction; cell-substrate junction; costamere; cytoskeleton; cytosol; extracellular region; fascia adherens; ficolin-1-rich granule lumen; focal adhesion; podosome; protein-containing complex; sarcolemma; secretory granule lumen; specific granule lumen
Molecular Function:  actin binding; alpha-catenin binding; beta-catenin binding; cadherin binding; dystroglycan binding; protein binding; structural molecule activity; ubiquitin protein ligase binding
Biological Process:  adherens junction assembly; apical junction assembly; axon extension; cell adhesion; cell-matrix adhesion; epithelial cell-cell adhesion; lamellipodium assembly; morphogenesis of an epithelium; muscle contraction; negative regulation of cell migration; neutrophil degranulation; platelet degranulation; protein localization to cell surface
Disease: Cardiomyopathy, Dilated, 1w
Reference #:  P18206 (UniProtKB)
Alt. Names/Synonyms: CMD1W; CMH15; Metavinculin; MVCL; VCL; VINC; Vinculin
Gene Symbols: VCL
Molecular weight: 123,799 Da
Basal Isoelectric point: 5.5  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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