uPA Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin. Belongs to the peptidase S1 family. Expressed in the prostate gland and prostate cancers. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Motility/polarity/chemotaxis; Protease; Secreted; Secreted, signal peptide
Chromosomal Location of mouse Ortholog: 14 A3|14 11.53 cM
Cellular Component:  cell surface; extracellular region; extracellular space; membrane
Molecular Function:  hydrolase activity; peptidase activity; protein binding; serine-type endopeptidase activity; serine-type peptidase activity
Biological Process:  angiogenesis; fibrinolysis; neuron death; plasminogen activation; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of ovulation; positive regulation of reactive oxygen species metabolic process; positive regulation of smooth muscle cell migration; proteolysis; regulation of cell adhesion mediated by integrin; regulation of cell proliferation; regulation of hepatocyte proliferation; regulation of signaling receptor activity; regulation of smooth muscle cell migration; regulation of smooth muscle cell-matrix adhesion; response to hypoxia; skeletal muscle tissue regeneration; smooth muscle cell migration; wound healing
Reference #:  P06869 (UniProtKB)
Alt. Names/Synonyms: plasminogen activator, urokinase; Plau; u-PA; U-plasminogen activator; uPA; UROK; Urokinase-type plasminogen activator; Urokinase-type plasminogen activator chain B; Urokinase-type plasminogen activator long chain A; Urokinase-type plasminogen activator short chain A
Gene Symbols: Plau
Molecular weight: 48,268 Da
Basal Isoelectric point: 8.53  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene