CAD This protein is a fusion protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase). In the central section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - alanine, aspartate and glutamate; EC; EC; EC; Hydrolase; Ligase; Nucleotide Metabolism - pyrimidine; Transferase
Chromosomal Location of Human Ortholog: 2p23.3
Cellular Component:  cell projection; cytosol; neuronal cell body; nuclear matrix; nucleoplasm; nucleus; protein-containing complex; terminal bouton
Molecular Function:  aspartate binding; aspartate carbamoyltransferase activity; ATP binding; carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity; dihydroorotase activity; enzyme binding; identical protein binding; protein kinase activity; zinc ion binding
Biological Process:  'de novo' pyrimidine nucleobase biosynthetic process; 'de novo' UMP biosynthetic process; animal organ regeneration; cellular response to drug; cellular response to epidermal growth factor stimulus; drug metabolic process; female pregnancy; glutamine metabolic process; heart development; lactation; liver development; peptidyl-threonine phosphorylation; protein autophosphorylation; pyrimidine nucleoside biosynthetic process; response to amine; response to caffeine; response to cortisol; response to insulin; response to starvation; response to testosterone
Disease: Congenital Disorder Of Glycosylation, Type Iz
Reference #:  P27708 (UniProtKB)
Alt. Names/Synonyms: Aspartate carbamoyltransferase; CAD; CAD protein; CAD trifunctional protein; carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; CDG1Z; Dihydroorotase; EIEE50; GATD4; Glutamine-dependent carbamoyl-phosphate synthase; multifunctional protein CAD; PYR1
Gene Symbols: CAD
Molecular weight: 242,984 Da
Basal Isoelectric point: 6.02  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene