IGF2R a multifunctional type I transmembrane protein receptor that binds insulin-like growth factor 2 at the cell surface and mannose-6-phosphate-tagged proteins in the trans-Golgi network. Also known as the cation-independent mannose-6 phosphate (M6P) receptor. Clears IGF2 from the cell surface to attenuate signaling, and transports M6P-tagged lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. M6P-tagged lysosomal enzymes bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Belongs to the MRL1/IGF2R family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.; Vesicle
Chromosomal Location of Human Ortholog: 6q25.3
Cellular Component:  cell surface; clathrin coat; clathrin-coated vesicle membrane; early endosome; endocytic vesicle; endosome; Golgi apparatus; integral component of plasma membrane; late endosome; lysosomal membrane; nuclear envelope lumen; perinuclear region of cytoplasm; plasma membrane; secretory granule membrane; trans-Golgi network; trans-Golgi network membrane; trans-Golgi network transport vesicle; transport vesicle
Molecular Function:  enzyme binding; G-protein alpha-subunit binding; identical protein binding; insulin-like growth factor II binding; insulin-like growth factor-activated receptor activity; phosphoprotein binding; protein binding; retinoic acid binding; signaling receptor activity
Biological Process:  animal organ regeneration; G protein-coupled receptor signaling pathway; insulin-like growth factor receptor signaling pathway; liver development; membrane organization; neutrophil degranulation; positive regulation of apoptotic process; post-embryonic development; receptor-mediated endocytosis; response to retinoic acid; signal transduction; spermatogenesis
Disease: Hepatocellular Carcinoma
Reference #:  P11717 (UniProtKB)
Alt. Names/Synonyms: 300 kDa mannose 6-phosphate receptor; cation-independent mannose-6 phosphate receptor; Cation-independent mannose-6-phosphate receptor; CD222; CI Man-6-P receptor; CI-MPR; CIMPR; IGF-II receptor; IGF2R; Insulin-like growth factor 2 receptor; Insulin-like growth factor II receptor; M6P-R; M6P/IGF2 receptor; M6P/IGF2R; M6PR; MPR 300; MPR1; MPRI
Gene Symbols: IGF2R
Molecular weight: 274,375 Da
Basal Isoelectric point: 5.64  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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