GATA1 Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS. Erythrocytes. 3 alternative splicing and alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: X A1.1|X 3.59 cM
Cellular Component:  nucleus; protein-DNA complex; transcription factor complex; transcriptional repressor complex
Molecular Function:  C2H2 zinc finger domain binding; chromatin binding; chromatin DNA binding; DNA binding; DNA binding, bending; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; enhancer sequence-specific DNA binding; metal ion binding; p53 binding; protein binding; RNA polymerase II distal enhancer sequence-specific DNA binding; RNA polymerase II proximal promoter sequence-specific DNA binding; RNA polymerase II regulatory region sequence-specific DNA binding; RNA polymerase II transcription factor binding; sequence-specific DNA binding; transcription regulatory region sequence-specific DNA binding; zinc ion binding
Biological Process:  basophil differentiation; cell development; cell-cell signaling; cellular response to thyroid hormone stimulus; dendritic cell differentiation; embryonic hemopoiesis; eosinophil differentiation; eosinophil fate commitment; erythrocyte development; erythrocyte differentiation; homeostasis of number of cells within a tissue; in utero embryonic development; male gonad development; megakaryocyte differentiation; myeloid cell differentiation; negative regulation of apoptotic process; negative regulation of bone mineralization; negative regulation of cell proliferation; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of transcription by RNA polymerase II; negative regulation of transcription regulatory region DNA binding; platelet aggregation; platelet formation; positive regulation of erythrocyte differentiation; positive regulation of osteoblast proliferation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; regulation of definitive erythrocyte differentiation; regulation of glycoprotein biosynthetic process; regulation of primitive erythrocyte differentiation; regulation of transcription, DNA-templated; transcription by RNA polymerase II; transcriptional activation by promoter-enhancer looping
Reference #:  P17679 (UniProtKB)
Alt. Names/Synonyms: Eryf1; Erythroid transcription factor; Gata; GATA binding protein 1; GATA-1; GATA-binding factor 1; GATA-binding protein 1; Gata1; GF-1; NF-E1 DNA-binding protein; OTTMUSP00000019548
Gene Symbols: Gata1
Molecular weight: 42,674 Da
Basal Isoelectric point: 8.91  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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GATA1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene