HLAB iso9
Involved in the presentation of foreign antigens to the immune system. Belongs to the MHC class I family. Note: This description may include information from UniProtKB.
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Protein type: Immunoglobulin superfamily; Membrane protein, integral |
Chromosomal Location of human Ortholog: 6p21.33 |
Cellular Component:
cell surface; early endosome membrane; endoplasmic reticulum; ER to Golgi transport vesicle membrane; external side of plasma membrane; extracellular space; Golgi apparatus; Golgi membrane; lumenal side of endoplasmic reticulum membrane; membrane; MHC class I protein complex; phagocytic vesicle membrane; plasma membrane; recycling endosome membrane; secretory granule membrane
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Molecular Function:
peptide antigen binding; protein binding; protein-folding chaperone binding; signaling receptor binding; TAP binding
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Biological Process:
adaptive immune response; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; antigen processing and presentation of endogenous peptide antigen via MHC class Ib; defense response; detection of bacterium; immune response; innate immune response; positive regulation of T cell mediated cytotoxicity; protection from natural killer cell mediated cytotoxicity; regulation of dendritic cell differentiation; regulation of interleukin-12 production; regulation of interleukin-6 production; regulation of T cell anergy
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Disease: Severe Cutaneous Adverse Reaction, Susceptibility To; Spondyloarthropathy, Susceptibility To, 1
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Reference #:
P01889_VAR_C349S
(UniProtKB)
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Alt. Names/Synonyms: AS; B-4901; HLA class I antigen HLA-B; HLA class I histocompatibility antigen, B alpha chain; HLA-B; HLAB; HLAB iso9; Human leukocyte antigen B; leukocyte antigen class I-B; major histocompatibility complex, class I, B; MHC class 1 antigen; MHC class I antigen HLA-B alpha chain; MHC class I antigen HLA-B heavy chain; MHC class I antigen SHCHA; MHC class I molecule; MHC HLA-B cell surface glycoprotein; MHC HLA-B transmembrane glycoprotein
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Gene Symbols: HLA-B
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Molecular weight:
40,444 Da
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Basal Isoelectric point:
5.57
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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