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HLAA
Involved in the presentation of foreign antigens to the immune system. Belongs to the MHC class I family. Note: This description may include information from UniProtKB.
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| Protein type: Immunoglobulin superfamily; Membrane protein, integral |
| Chromosomal Location of human Ortholog: 6p22.1 |
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Cellular Component:
cell surface; early endosome membrane; endoplasmic reticulum; endoplasmic reticulum exit site; endoplasmic reticulum membrane; ER to Golgi transport vesicle membrane; Golgi apparatus; Golgi medial cisterna; Golgi membrane; MHC class I peptide loading complex; MHC class I protein complex; phagocytic vesicle membrane; plasma membrane; recycling endosome membrane
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Molecular Function:
beta-2-microglobulin binding; CD8 receptor binding; peptide antigen binding; protein binding; signaling receptor binding; T cell receptor binding; TAP binding; TAP complex binding
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Biological Process:
antibacterial humoral response; antigen processing and presentation of endogenous peptide antigen via MHC class I; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; antigen processing and presentation of exogenous peptide antigen via MHC class I; CD8-positive, alpha-beta T cell activation; defense response to Gram-positive bacterium; detection of bacterium; immune response; innate immune response; positive regulation of CD8-positive, alpha-beta T cell activation; positive regulation of CD8-positive, alpha-beta T cell proliferation; positive regulation of memory T cell activation; positive regulation of T cell cytokine production; positive regulation of T cell mediated cytotoxicity; positive regulation of type II interferon production; protection from natural killer cell mediated cytotoxicity; T cell mediated cytotoxicity; T cell mediated cytotoxicity directed against tumor cell target; T cell receptor signaling pathway
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Disease: Severe Cutaneous Adverse Reaction, Susceptibility To
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Reference #:
P04439
(UniProtKB)
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Alt. Names/Synonyms: HLA class I histocompatibility antigen, A alpha chain; HLA class I histocompatibility antigen, A-1 alpha chain; HLA-A; HLAA; Human leukocyte antigen A; leukocyte antigen class I-A; major histocompatibility complex, class I, A; MHC class I antigen HLA-A heavy chain
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Gene Symbols: HLA-A
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Molecular weight:
40,841 Da
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Basal Isoelectric point:
5.66
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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