HLAA Involved in the presentation of foreign antigens to the immune system. Belongs to the MHC class I family. Note: This description may include information from UniProtKB.
Protein type: Immunoglobulin superfamily; Membrane protein, integral
Chromosomal Location of human Ortholog: 6p22.1
Cellular Component:  cell surface; early endosome membrane; endoplasmic reticulum; endoplasmic reticulum exit site; endoplasmic reticulum membrane; ER to Golgi transport vesicle membrane; Golgi apparatus; Golgi medial cisterna; Golgi membrane; MHC class I peptide loading complex; MHC class I protein complex; phagocytic vesicle membrane; plasma membrane; recycling endosome membrane
Molecular Function:  beta-2-microglobulin binding; CD8 receptor binding; peptide antigen binding; protein binding; signaling receptor binding; T cell receptor binding; TAP binding; TAP complex binding
Biological Process:  antibacterial humoral response; antigen processing and presentation of endogenous peptide antigen via MHC class I; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; antigen processing and presentation of exogenous peptide antigen via MHC class I; CD8-positive, alpha-beta T cell activation; defense response to Gram-positive bacterium; detection of bacterium; immune response; innate immune response; positive regulation of CD8-positive, alpha-beta T cell activation; positive regulation of CD8-positive, alpha-beta T cell proliferation; positive regulation of memory T cell activation; positive regulation of T cell cytokine production; positive regulation of T cell mediated cytotoxicity; positive regulation of type II interferon production; protection from natural killer cell mediated cytotoxicity; T cell mediated cytotoxicity; T cell mediated cytotoxicity directed against tumor cell target; T cell receptor signaling pathway
Disease: Severe Cutaneous Adverse Reaction, Susceptibility To
Reference #:  P04439 (UniProtKB)
Alt. Names/Synonyms: HLA class I histocompatibility antigen, A alpha chain; HLA class I histocompatibility antigen, A-1 alpha chain; HLA-A; HLAA; Human leukocyte antigen A; leukocyte antigen class I-A; major histocompatibility complex, class I, A; MHC class I antigen HLA-A heavy chain
Gene Symbols: HLA-A
Molecular weight: 40,841 Da
Basal Isoelectric point: 5.66  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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HLAA

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein