ADAM15 Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain. 11 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; EC 3.4.24.-; Membrane protein, integral; Motility/polarity/chemotaxis; Protease
Chromosomal Location of Human Ortholog: 3 F1|3 39.07 cM
Cellular Component:  cell junction; cell projection; cell surface; cilium; cytoplasmic vesicle; extracellular exosome; integral component of membrane; membrane; motile cilium
Molecular Function:  hydrolase activity; integrin binding; metal ion binding; metalloendopeptidase activity; metallopeptidase activity; peptidase activity; protein binding; SH3 domain binding
Biological Process:  angiogenesis; cardiac epithelial to mesenchymal transition; cell adhesion; cellular response to phorbol 13-acetate 12-myristate; collagen catabolic process; immune response to tumor cell; innate immune response; integrin-mediated signaling pathway; negative regulation of cell growth; negative regulation of cell migration; negative regulation of cell-matrix adhesion; negative regulation of receptor binding; proteolysis
Reference #:  O88839 (UniProtKB)
Alt. Names/Synonyms: a disintegrin and metallopeptidase domain 15 (metargidin); a disintegrin and metalloprotease domain 15 (metargidin); a disintegrin and metalloproteinase domain 15 (metargidin); AD56; ADA15; ADAM 15; Adam15; disintegrin and metalloprotease 15; Disintegrin and metalloproteinase domain-containing protein 15; MDC-15; Mdc15; Metalloprotease RGD disintegrin protein; Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15; Metargidin; OTTMUSP00000024867; OTTMUSP00000024868
Gene Symbols: Adam15
Molecular weight: 92,664 Da
Basal Isoelectric point: 6.09  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene