ADAM15 Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain. Expressed in colon and small intestine. Expressed in airway smooth muscle and glomerular mesangial cells (at protein level). Ubiquitously expressed. Overexpressed in atherosclerotic lesions. Constitutively expressed in cultured endothelium and smooth muscle. Expressed in chondrocytes. Expressed in airway smooth muscle and glomerular mesangial cells. 13 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; EC 3.4.24.-; Membrane protein, integral; Motility/polarity/chemotaxis; Protease
Chromosomal Location of Human Ortholog: 3 F1|3 39.07 cM
Cellular Component:  cell junction; cell projection; cell surface; cilium; cytoplasmic vesicle; extracellular exosome; integral component of membrane; membrane; motile cilium
Molecular Function:  hydrolase activity; integrin binding; metal ion binding; metalloendopeptidase activity; metallopeptidase activity; peptidase activity; protein binding; SH3 domain binding
Biological Process:  angiogenesis; cardiac epithelial to mesenchymal transition; cell adhesion; cellular response to phorbol 13-acetate 12-myristate; collagen catabolic process; immune response to tumor cell; innate immune response; integrin-mediated signaling pathway; negative regulation of cell growth; negative regulation of cell migration; negative regulation of cell-matrix adhesion; negative regulation of receptor binding; proteolysis
Reference #:  O88839 (UniProtKB)
Alt. Names/Synonyms: a disintegrin and metallopeptidase domain 15 (metargidin); a disintegrin and metalloprotease domain 15 (metargidin); a disintegrin and metalloproteinase domain 15 (metargidin); AD56; ADA15; ADAM 15; Adam15; disintegrin and metalloprotease 15; Disintegrin and metalloproteinase domain-containing protein 15; MDC-15; Mdc15; Metalloprotease RGD disintegrin protein; Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15; metar; Metargidin; OTTMUSP00000024867; OTTMUSP00000024868
Gene Symbols: Adam15
Molecular weight: 92,664 Da
Basal Isoelectric point: 6.09  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene