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eNOS
Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. Isoform eNOS13C: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1. Belongs to the NOS family. Platelets, placenta, liver and kidney. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase |
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Cellular Component:
caveola; cytoskeleton; Golgi apparatus
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Molecular Function:
calmodulin binding; heme binding; metal ion binding; NADP binding
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Biological Process:
vasodilation
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Reference #:
Q7YSG7
(UniProtKB)
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Alt. Names/Synonyms: eNOS; Nitric oxide synthase; NOS3
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Gene Symbols: NOS3
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Molecular weight:
133,331 Da
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Basal Isoelectric point:
6.61
Predict pI for various phosphorylation states
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CST Pathways:
AMPK Signaling
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Angiogenesis
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PI3K/Akt Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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