PTPN2 a type 2 non-receptor phospho-tyrosine-protein phosphatase (PTP). Two alternatively spliced isoforms are differenyially expressed. Isoform A is a major PTP expressed in human tissues, while isoform B is expressed mainly in T-cells and in placenta. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor)
Chromosomal Location of Human Ortholog: 18|18 E1
Cellular Component:  cytoplasm; cytosol; endoplasmic reticulum; endoplasmic reticulum-Golgi intermediate compartment; membrane; nucleoplasm; nucleus
Molecular Function:  hydrolase activity; integrin binding; non-membrane spanning protein tyrosine phosphatase activity; phosphatase activity; phosphoprotein phosphatase activity; protein binding; protein kinase binding; protein tyrosine phosphatase activity; receptor tyrosine kinase binding; STAT family protein binding; syntaxin binding
Biological Process:  B cell differentiation; dephosphorylation; erythrocyte differentiation; glucose homeostasis; insulin receptor signaling pathway; negative regulation of cell proliferation; negative regulation of chemotaxis; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of ERK1 and ERK2 cascade; negative regulation of inflammatory response; negative regulation of insulin receptor signaling pathway; negative regulation of interferon-gamma-mediated signaling pathway; negative regulation of interleukin-2-mediated signaling pathway; negative regulation of interleukin-4-mediated signaling pathway; negative regulation of interleukin-6-mediated signaling pathway; negative regulation of lipid storage; negative regulation of macrophage colony-stimulating factor signaling pathway; negative regulation of macrophage differentiation; negative regulation of platelet-derived growth factor receptor-beta signaling pathway; negative regulation of positive thymic T cell selection; negative regulation of protein tyrosine kinase activity; negative regulation of T cell receptor signaling pathway; negative regulation of transcription by RNA polymerase II; negative regulation of tumor necrosis factor-mediated signaling pathway; negative regulation of type I interferon-mediated signaling pathway; negative regulation of tyrosine phosphorylation of STAT protein; peptidyl-tyrosine dephosphorylation; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; positive regulation of gluconeogenesis; positive regulation of PERK-mediated unfolded protein response; protein dephosphorylation; regulation of hepatocyte growth factor receptor signaling pathway; T cell differentiation
Reference #:  Q06180 (UniProtKB)
Alt. Names/Synonyms: AI325124; MPTP; protein tyrosine phosphatase, non-receptor type 2; Protein-tyrosine phosphatase PTP-2; PTN2; Ptpn2; Ptpt; T cell protein-tyrosine phosphatase; TC-PTP; Tyrosine-protein phosphatase non-receptor type 2
Gene Symbols: Ptpn2
Molecular weight: 47,360 Da
Basal Isoelectric point: 8.61  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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PTPN2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene