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ENaC-gamma
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1G subfamily. Expressed in kidney (at protein level). Note: This description may include information from UniProtKB.
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| Protein type: Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel |
| Chromosomal Location of rat Ortholog: 1q36 |
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Cellular Component:
apical plasma membrane; cell surface; external side of plasma membrane; extracellular exosome; membrane; nucleoplasm; plasma membrane; sodium channel complex
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Molecular Function:
ligand-gated sodium channel activity; monoatomic ion channel activity; protein binding; sodium channel activity; sodium ion transmembrane transporter activity; WW domain binding
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Biological Process:
cellular response to acidic pH; cellular response to aldosterone; cellular response to vasopressin; intracellular sodium ion homeostasis; multicellular organismal-level water homeostasis; regulation of blood pressure; response to hypoxia; sensory perception of salty taste; sensory perception of sour taste; sodium ion homeostasis; sodium ion import across plasma membrane; sodium ion transmembrane transport; sodium ion transport; wound healing, spreading of epidermal cells
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Reference #:
P37091
(UniProtKB)
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Alt. Names/Synonyms: amiloride sensitive sodium channel gamma1 subunit; Amiloride-sensitive sodium channel subunit gamma; ENaC; ENAC gamma; ENaC-gamma; ENaCG; Epithelial Na(+) channel subunit gamma; epithelial sodium channel gamma subunit; Gamma-ENaC; Gamma-NaCH; Nonvoltage-gated sodium channel 1 subunit gamma; SCNEG; Scnn1g; SCNNG; Sodium channel nonvoltage-gated 1 gamma (epithelial); sodium channel, nonvoltage-gated 1 gamma; Sodium channel, nonvoltage-gated 1, gamma (epithelial); sodium channel, nonvoltage-gated, type I, gamma
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Gene Symbols: Scnn1g
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Molecular weight:
74,066 Da
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Basal Isoelectric point:
8.1
Predict pI for various phosphorylation states
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CST Pathways:
Insulin Receptor Signaling
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