ENaC-gamma Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1G subfamily. Expressed in kidney (at protein level). Note: This description may include information from UniProtKB.
Protein type: Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel
Chromosomal Location of Human Ortholog: 1q36
Cellular Component:  apical plasma membrane; cell surface; external side of plasma membrane; extracellular exosome; integral component of membrane; integral component of plasma membrane; membrane; nucleoplasm; plasma membrane; sodium channel complex
Molecular Function:  ion channel activity; ligand-gated sodium channel activity; protein binding; WW domain binding
Biological Process:  multicellular organismal water homeostasis; response to hypoxia; sensory perception of taste; sodium ion homeostasis; sodium ion transmembrane transport; sodium ion transport; wound healing, spreading of epidermal cells
Reference #:  P37091 (UniProtKB)
Alt. Names/Synonyms: amiloride sensitive sodium channel gamma1 subunit; Amiloride-sensitive sodium channel subunit gamma; ENaC; ENAC gamma; ENaC-gamma; ENaCG; Epithelial Na(+) channel subunit gamma; epithelial sodium channel gamma subunit; Gamma-ENaC; Gamma-NaCH; Nonvoltage-gated sodium channel 1 subunit gamma; SCNEG; Scnn1g; SCNNG; Sodium channel nonvoltage-gated 1 gamma (epithelial); sodium channel, nonvoltage-gated 1 gamma; Sodium channel, nonvoltage-gated 1, gamma (epithelial); sodium channel, nonvoltage-gated, type I, gamma
Gene Symbols: Scnn1g
Molecular weight: 74,066 Da
Basal Isoelectric point: 8.1  Predict pI for various phosphorylation states
CST Pathways:  Insulin Receptor Signaling
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene