ENaC-gamma Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1G subfamily. Expressed in kidney (at protein level). Note: This description may include information from UniProtKB.
Protein type: Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel
Chromosomal Location of human Ortholog: 16p12.2
Cellular Component:  apical plasma membrane; external side of plasma membrane; extracellular exosome; integral component of plasma membrane; nucleoplasm; plasma membrane; sodium channel complex
Molecular Function:  ion channel activity; protein binding; sodium channel activity; WW domain binding
Biological Process:  excretion; ion transmembrane transport; multicellular organismal water homeostasis; response to stimulus; sensory perception of taste; sodium ion homeostasis; sodium ion transmembrane transport; sodium ion transport
Disease: Bronchiectasis With Or Without Elevated Sweat Chloride 3; Liddle Syndrome 2; Pseudohypoaldosteronism, Type I, Autosomal Recessive
Reference #:  P51170 (UniProtKB)
Alt. Names/Synonyms: amiloride-sensitive epithelial sodium channel gamma subunit; amiloride-sensitive sodium channel gamma-subunit; Amiloride-sensitive sodium channel subunit gamma; BESC3; ENaC gamma; ENaC gamma subunit; ENaC-gamma; ENaCG; ENaCgamma; Epithelial Na(+) channel subunit gamma; Gamma-ENaC; Gamma-NaCH; LDLS2; Nonvoltage-gated sodium channel 1 subunit gamma; PHA1; SCNEG; SCNN1G; SCNNG; sodium channe epithelial 1 gamma subunit; sodium channel epithelial 1 gamma subunit; sodium channel epithelial 1 subunit gamma; sodium channel, non-voltage-gated 1, gamma subunit; sodium channel, nonvoltage-gated 1, gamma
Gene Symbols: SCNN1G
Molecular weight: 74,270 Da
Basal Isoelectric point: 7.47  Predict pI for various phosphorylation states
CST Pathways:  Insulin Receptor Signaling
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB