ENaC-beta Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1B subfamily. Detected in placenta, lung and kidney (PubMed:7762608). Expressed in kidney (at protein level) (PubMed:22207244). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel
Chromosomal Location of Human Ortholog: 16p12.2
Cellular Component:  apical plasma membrane; cytoplasmic vesicle membrane; external side of plasma membrane; extracellular exosome; integral component of plasma membrane; plasma membrane; sodium channel complex
Molecular Function:  protein binding; WW domain binding
Biological Process:  excretion; ion transmembrane transport; multicellular organismal water homeostasis; response to stimulus; sensory perception of taste; sodium ion homeostasis; sodium ion transmembrane transport; sodium ion transport
Disease: Bronchiectasis With Or Without Elevated Sweat Chloride 1; Liddle Syndrome; Pseudohypoaldosteronism, Type I, Autosomal Recessive
Reference #:  P51168 (UniProtKB)
Alt. Names/Synonyms: Amiloride-sensitive sodium channel subunit beta; amiloride-sensitive sodium channel subunit beta 1; BESC1; Beta-ENaC; Beta-NaCH; ENaC beta; ENaC-beta; ENaCB; ENaCbeta; Epithelial Na(+) channel subunit beta; epithelial sodium channel beta-2 subunit; epithelial sodium channel beta-3 subunit; LIDLS1; mutant sodium channel epithelial 1 beta subunit; nasal epithelial sodium channel beta subunit; Nonvoltage-gated sodium channel 1 subunit beta; SCNEB; SCNN1B; SCNNB; sodium channel epithelial 1 beta subunit; sodium channel epithelial 1 subunit beta; sodium channel, non-voltage-gated 1, beta subunit; sodium channel, nonvoltage-gated 1, beta
Gene Symbols: SCNN1B
Molecular weight: 72,659 Da
Basal Isoelectric point: 5.89  Predict pI for various phosphorylation states
CST Pathways:  Insulin Receptor Signaling
Select Structure to View Below


Protein Structure Not Found.

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