RARB Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. The RXRA/RARB heterodimer can act as a repressor on the DR1 element and as an activator on the DR5 element. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function. Belongs to the nuclear hormone receptor family. NR1 subfamily. Expressed in aortic endothelial cells (at protein level). 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Nuclear receptor; Oncoprotein
Chromosomal Location of rat Ortholog: 15p16
Cellular Component:  nucleoplasm; nucleus
Molecular Function:  DNA-binding transcription factor activity; heterocyclic compound binding; nuclear receptor activity; nuclear retinoid X receptor binding; protein binding; protein-containing complex binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; zinc ion binding
Biological Process:  apoptotic process; bone development; cell differentiation; cell population proliferation; DNA-templated transcription; embryonic digestive tract development; embryonic eye morphogenesis; embryonic hindlimb morphogenesis; glandular epithelial cell development; growth plate cartilage development; hormone-mediated signaling pathway; multicellular organism growth; negative regulation of apoptotic process; negative regulation of cartilage development; negative regulation of chondrocyte differentiation; negative regulation of stem cell proliferation; negative regulation of transcription by RNA polymerase II; neural precursor cell proliferation; neurogenesis; outflow tract septum morphogenesis; positive regulation of apoptotic process; positive regulation of cell population proliferation; positive regulation of programmed cell death; positive regulation of transcription by RNA polymerase II; programmed cell death; regulation of DNA-templated transcription; regulation of myelination; retina development in camera-type eye; retinal pigment epithelium development; retinoic acid receptor signaling pathway; stem cell proliferation; striatum development; ureteric bud development; ventricular cardiac muscle cell differentiation
Reference #:  D3ZFD9 (UniProtKB)
Alt. Names/Synonyms: Rarb; Retinoic acid receptor, beta
Gene Symbols: Rarb
Molecular weight: 50,324 Da
Basal Isoelectric point: 7.45  Predict pI for various phosphorylation states
CST Pathways:  Wnt/ß-Catenin Signaling
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RARB

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  Reactome  |  BioGPS  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  Ensembl Protein