ENaC-beta Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1B subfamily. Detected in placenta, lung and kidney (PubMed:7762608). Expressed in kidney (at protein level) (PubMed:22207244). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel
Chromosomal Location of Human Ortholog: 1q36
Cellular Component:  apical plasma membrane; cell surface; cytoplasmic vesicle membrane; external side of plasma membrane; extracellular exosome; integral component of membrane; integral component of plasma membrane; membrane; sodium channel complex
Molecular Function:  ligand-gated sodium channel activity; protein binding; WW domain binding
Biological Process:  multicellular organismal water homeostasis; regulation of sodium ion transport; response to hypoxia; sensory perception of taste; sodium ion homeostasis; sodium ion transmembrane transport; sodium ion transport; wound healing, spreading of epidermal cells
Reference #:  P37090 (UniProtKB)
Alt. Names/Synonyms: Amiloride-sensitive sodium channel subunit beta; Beta-ENaC; Beta-NaCH; ENaC beta; ENaC-beta; ENaCB; Epithelial Na(+) channel subunit beta; Nonvoltage-gated sodium channel 1 subunit beta; RNENACB; SCNEB; Scnn1b; SCNNB; sodium channel, nonvoltage-gated 1 beta; sodium channel, nonvoltage-gated, type I, beta
Gene Symbols: Scnn1b
Molecular weight: 71,995 Da
Basal Isoelectric point: 5.95  Predict pI for various phosphorylation states
CST Pathways:  Insulin Receptor Signaling
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene