SIIR May be involved in transcriptional regulation. Modulates various viral and cellular promoters in a promoter context-dependent manner. For example, transcription from the FOS promoter is increased, while Rous sarcoma virus (RSV) long terminal repeat (LTR) promoter activity is repressed. Does not bind DNA directly. Belongs to the TFS-II family. TFA subfamily. Expressed in all tissues examined. Highly expressed in heart, ovary, prostate and skeletal muscle. Moderately expressed in brain, placenta, testis and small intestine. Weakly expressed in lung, liver and spleen. Expressed in several cancer cell lines. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Transcription initiation complex
Chromosomal Location of Human Ortholog: Xq22.2
Cellular Component:  nucleoplasm
Molecular Function:  DNA-binding transcription factor activity
Biological Process:  negative regulation of transcription by RNA polymerase II
Reference #:  Q15170 (UniProtKB)
Alt. Names/Synonyms: Nuclear phosphoprotein p21/SIIR; p21; pp21; SIIR; TCAL1; TCEA-like protein 1; TCEAL1; transcription elongation factor A (SII)-like 1; Transcription elongation factor A protein-like 1; Transcription elongation factor S-II protein-like 1
Gene Symbols: TCEAL1
Molecular weight: 18,354 Da
Basal Isoelectric point: 11.2  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene