TCF4 Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription. Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'. Expressed in adult heart, brain, placenta, skeletal muscle and to a lesser extent in the lung. In developing embryonic tissues, expression mostly occurs in the brain. 16 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 18|18 E2
Cellular Component:  beta-catenin-TCF complex; beta-catenin-TCF7L2 complex; nuclear chromatin; nucleus; transcription factor complex
Molecular Function:  bHLH transcription factor binding; chromatin binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; double-stranded DNA binding; E-box binding; identical protein binding; protein binding; protein C-terminus binding; protein dimerization activity; protein heterodimerization activity; protein homodimerization activity; protein self-association; RNA polymerase II proximal promoter sequence-specific DNA binding; TFIIB-class transcription factor binding; transcription corepressor activity
Biological Process:  cell differentiation; DNA-templated transcription, initiation; endothelial cell activation; multicellular organism development; negative regulation of angiogenesis; negative regulation of gene expression; negative regulation of transcription by RNA polymerase II; nervous system development; positive regulation of neuron differentiation; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; protein-DNA complex assembly; regulation of transcription, DNA-templated; regulation of vascular endothelial growth factor signaling pathway; transcription initiation from RNA polymerase II promoter
Reference #:  Q60722 (UniProtKB)
Alt. Names/Synonyms: 5730422P05Rik; ASP-I2; bHLHb1; bHLHb19; Class A helix-loop-helix transcription factor ME2; E2-2; E2.2; Immunoglobulin transcription factor 2; immunoglobulin transcription factor-2; ITF-; ITF-2; ITF-2b; Itf2; ME2; MITF-; MITF-2; MITF-2A; MITF-2B; OTTMUSP00000023158; SEF-; SEF-2; Sef2; SEF2-; SEF2-1; SL3-3 enhancer factor 2; TCF-4; Tcf4; TFE; Transcription factor 4; Transcription factor 4 (Immunoglobulin transcription factor 2) (ITF-2) (MITF-2) (SL3-3 enhancer factor 2) (SEF-2) (Class A helix-loop-helix transcription factor ME2)
Gene Symbols: Tcf4
Molecular weight: 71,625 Da
Basal Isoelectric point: 6.67  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene