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DAB2
an adaptor protein that functions as clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Involved in several receptor-mediated signaling pathways. Required for recycling of the TGF-beta receptor. Involved in endocytosis of CFTR and of megalin/LRP2 lipoprotein receptor during embryonal development. Interacts with Grb2, myosin VI, SMAD2/3, DIP1/2, Dvl-3, the integrin betasubunit, and c-Src. Negatively regulates canonical Wnt signaling by stabilizing the beta-catenin degradation complex. A component of the CSF-1 signal transduction pathway. Phosphorylated DAB2 inhibits adhesion and integrin signaling. Three alternatively spliced isoforms are described. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Tumor suppressor |
| Chromosomal Location of rat Ortholog: 2q16 |
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Cellular Component:
apical plasma membrane; clathrin coat of coated pit; clathrin-coated pit; clathrin-coated vesicle; clathrin-coated vesicle membrane; cytoplasm; fibrillar center; intracellular membrane-bounded organelle; nucleus; perinuclear region of cytoplasm; plasma membrane
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Molecular Function:
AP-2 adaptor complex binding; cargo receptor activity; clathrin adaptor activity; clathrin binding; integrin binding; low-density lipoprotein particle receptor binding; phosphatidylinositol binding; phosphatidylinositol-4,5-bisphosphate binding; protein binding; SMAD binding
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Biological Process:
cell morphogenesis involved in differentiation; cellular response to epidermal growth factor stimulus; cellular response to transforming growth factor beta stimulus; clathrin coat assembly; endocytosis; endoderm development; establishment of localization in cell; extrinsic apoptotic signaling pathway; hematopoietic stem cell proliferation; in utero embryonic development; integrin-mediated signaling pathway; leading edge cell differentiation; myeloid cell differentiation; negative regulation of androgen receptor signaling pathway; negative regulation of apoptotic process; negative regulation of canonical Wnt signaling pathway; negative regulation of cell growth; negative regulation of epithelial cell proliferation; negative regulation of ERK1 and ERK2 cascade; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of neuron projection development; negative regulation of protein binding; negative regulation of protein localization to plasma membrane; negative regulation of transcription by RNA polymerase II; pinocytosis; positive regulation of aldosterone biosynthetic process; positive regulation of aldosterone secretion; positive regulation of cell adhesion; positive regulation of cell migration; positive regulation of clathrin-dependent endocytosis; positive regulation of early endosome to late endosome transport; positive regulation of endocytosis; positive regulation of epithelial to mesenchymal transition; positive regulation of integrin-mediated signaling pathway; positive regulation of JNK cascade; positive regulation of pathway-restricted SMAD protein phosphorylation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein phosphorylation; positive regulation of receptor internalization; positive regulation of receptor recycling; positive regulation of SMAD protein signal transduction; positive regulation of substrate adhesion-dependent cell spreading; positive regulation of transcription by RNA polymerase II; positive regulation of transcription elongation by RNA polymerase II; positive regulation of transforming growth factor beta receptor signaling pathway; positive regulation of Wnt signaling pathway, planar cell polarity pathway; protein transport; receptor-mediated endocytosis; regulation of Rho-dependent protein serine/threonine kinase activity; renal protein absorption; response to salt; response to steroid hormone; Wnt signaling pathway
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Reference #:
O88797
(UniProtKB)
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Alt. Names/Synonyms: C9; Dab2; Disabled homolog 2; disabled homolog 2 (Drosophila); disabled homolog 2 mitogen-responsive phosphoprotein; DOC-2; DOC-2 p82 isoform; Doc2; Mitogen-responsive phosphoprotein
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Gene Symbols: Dab2
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Molecular weight:
82,377 Da
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Basal Isoelectric point:
5.82
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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