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Srcasm
Probable adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. May promote FYN activation, possibly by disrupting intramolecular SH3-dependent interactions. Belongs to the TOM1 family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold |
| Chromosomal Location of human Ortholog: 17q22 |
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Cellular Component:
cytoplasm; cytosol; endosome; endosome membrane; Golgi stack; lysosome; membrane
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Molecular Function:
clathrin binding; phosphatidylinositol binding; protein binding; protein kinase activator activity; protein kinase binding; SH3 domain binding; ubiquitin binding
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Biological Process:
activation of protein kinase activity; negative regulation of mitotic nuclear division; positive regulation of protein autophosphorylation; protein transport; regulation of DNA biosynthetic process; signal transduction; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
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Reference #:
O75674
(UniProtKB)
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Alt. Names/Synonyms: OK/KNS-CL.3; Src activating and signaling molecule; Src-activating and signaling molecule protein; SRCASM; target of myb 1-like 1; Target of Myb-like protein 1; target of myb1 (chicken)-like 1; target of myb1 like 1 membrane trafficking protein; target of myb1-like 1; TM1L1; TOM1-like protein 1; TOM1L1
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Gene Symbols: TOM1L1
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Molecular weight:
52,989 Da
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Basal Isoelectric point:
5.11
Predict pI for various phosphorylation states
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