Srcasm an adapter protein that is a src-family kinase substrate. When phosphorylated, it binds src-family kinases and targets them for lysosomal-dependent degradation. EGF triggers a transient association of phosphorylated Srcasm with EGFR via Grb2 and Shc initiating the endocytosis of the ligand-receptor complex. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. Involved in multivesicular body (MVB) formation, viral egress from the cell, and cytokinesis. Belongs to the TOM1 family. Interacts with FYN, GRB2 and PIK3R1 when phosphorylated. The PTAP sequence in the GAT domain and the PSAP sequence in the C-terminal region are responsible for its interaction with the UEV domain of Tsg101, a component of the ESCRT-1 complex. Localizes to the multivesicular body (MVB) that is involved in targeting endosomal proteins for lysosomal degradation. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 17q22
Cellular Component:  cytoplasm; cytosol; endosome; endosome membrane; Golgi stack; lysosome
Molecular Function:  clathrin binding; protein binding; protein kinase activator activity; protein kinase binding; SH3 domain binding; ubiquitin binding
Biological Process:  activation of protein kinase activity; intracellular protein transport; negative regulation of mitotic nuclear division; positive regulation of protein autophosphorylation; signal transduction; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
Reference #:  O75674 (UniProtKB)
Alt. Names/Synonyms: OK/KNS-CL.3; Src activating and signaling molecule; Src-activating and signaling molecule protein; SRCASM; target of myb 1-like 1; Target of Myb-like protein 1; target of myb1 (chicken)-like 1; target of myb1-like 1; TM1L1; TOM1-like protein 1; TOM1L1
Gene Symbols: TOM1L1
Molecular weight: 52,989 Da
Basal Isoelectric point: 5.11  Predict pI for various phosphorylation states
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Srcasm

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene