Srcasm Probable adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. May promote FYN activation, possibly by disrupting intramolecular SH3-dependent interactions. Belongs to the TOM1 family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of human Ortholog: 17q22
Cellular Component:  cytoplasm; cytosol; endosome; endosome membrane; Golgi stack; lysosome
Molecular Function:  clathrin binding; protein binding; protein kinase activator activity; protein kinase binding; SH3 domain binding; ubiquitin binding
Biological Process:  activation of protein kinase activity; intracellular protein transport; negative regulation of mitotic nuclear division; positive regulation of protein autophosphorylation; signal transduction; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
Reference #:  O75674 (UniProtKB)
Alt. Names/Synonyms: OK/KNS-CL.3; Src activating and signaling molecule; Src-activating and signaling molecule protein; SRCASM; target of myb 1-like 1; Target of Myb-like protein 1; target of myb1 (chicken)-like 1; target of myb1 like 1 membrane trafficking protein; target of myb1-like 1; TM1L1; TOM1-like protein 1; TOM1L1
Gene Symbols: TOM1L1
Molecular weight: 52,989 Da
Basal Isoelectric point: 5.11  Predict pI for various phosphorylation states
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Srcasm

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene