Srcasm Probable adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. May promote FYN activation, possibly by disrupting intramolecular SH3-dependent interactions. Belongs to the TOM1 family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of mouse Ortholog: 11 D|11 55.47 cM
Cellular Component:  cytoplasm; cytosol; endosome; Golgi apparatus; membrane
Molecular Function:  clathrin binding; phosphatidylinositol binding; protein binding; protein kinase activator activity; protein kinase binding; SH3 domain binding; ubiquitin binding
Biological Process:  activation of protein kinase activity; negative regulation of mitotic nuclear division; positive regulation of protein autophosphorylation; protein transport; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  Q923U0 (UniProtKB)
Alt. Names/Synonyms: 2310045L10Rik; C80573; Jerry protein; OTTMUSP00000001540; Src activating and signaling molecule; Src-activating and signaling molecule protein; Srcasm; Target of Myb-like protein 1; target of myb1-like 1 (chicken); TM1L1; TOM1-like protein 1; Tom1l1
Gene Symbols: Tom1l1
Molecular weight: 52,695 Da
Basal Isoelectric point: 5.21  Predict pI for various phosphorylation states
Select Structure to View Below

Srcasm

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene