NDR2 a non-receptor S/T kinase of the AGC group. Activated by binding of S100B which releases autoinhibitory N-lobe interactions, enabling ATP to bind followed by autophosphorylation of a serine in the kinase domain. A threonine in the C-terminal domain then undergoes calcium-dependent phosphorylation by an upstream kinase. Interactions between the phosphorylated threonine and the N-lobe promote additional structural changes that complete the activation of the kinase. Autoinhibition is also released by the binding of MOB1/MOBKL1A and MOB2/HCCA2 to the N-terminal of STK38L. May be involved in the regulation of structural processes in neuronal cells. Note: This description may include information from UniProtKB.
Protein type: AGC group; EC; Kinase, protein; NDR family; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 6|6 G3
Cellular Component:  actin cytoskeleton; cytoplasm; cytoskeleton; cytosol; membrane
Molecular Function:  actin binding; ATP binding; kinase activity; magnesium ion binding; metal ion binding; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  peptidyl-serine phosphorylation; phosphorylation; protein amino acid phosphorylation; regulation of cellular component organization and biogenesis
Reference #:  Q7TSE6 (UniProtKB)
Alt. Names/Synonyms: 4930473A22Rik; B230328I19; Ndr2; NDR2 protein kinase; Ndr54; Nuclear Dbf2-related kinase 2; OTTMUSP00000031174; serine/threonine kinase 38 like; Serine/threonine-protein kinase 38-like; ST38L; Stk38l
Gene Symbols: Stk38l
Molecular weight: 53,786 Da
Basal Isoelectric point: 6.5  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein