GLUT4 an integral membrane facilitative glucose transporter. One of 13 members of the human equilibrative glucose transport protein family. Its surface expression is regulated by insulin. Has two internalization sequences, a dileucine repeat present in the C-terminus and a FxxY motif in the amino-terminal end. Associates with an intracellular tubulo-vesicular compartment under low plasma conditions. The binding of insulin to the insulin receptor (a typosine kinase) leads to the rapid translocation of GLUT4 to the cell surface, increasing cellular glucose transport activity. Its translocation to the plasma membrane is also stimulated by exercise, but independent from insulin signaling. This insulin-independent pathway may be regulated by AMPK. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 10q24
Cellular Component:  cell surface; clathrin-coated pit; clathrin-coated vesicle; cytoplasm; cytoplasmic vesicle membrane; cytosol; endomembrane system; endosome; external side of plasma membrane; extracellular exosome; insulin-responsive compartment; integral component of membrane; integral component of plasma membrane; intracellular membrane-bounded organelle; membrane; membrane raft; multivesicular body; perinuclear region of cytoplasm; plasma membrane; presynapse; sarcolemma; sarcoplasmic reticulum; T-tubule; trans-Golgi network transport vesicle; vesicle membrane
Molecular Function:  D-glucose transmembrane transporter activity; glucose transmembrane transporter activity; protein binding
Biological Process:  amylopectin biosynthetic process; brown fat cell differentiation; cellular response to hypoxia; cellular response to insulin stimulus; cellular response to osmotic stress; cellular response to tumor necrosis factor; glucose homeostasis; glucose import; glucose import in response to insulin stimulus; glucose transmembrane transport; regulation of synaptic vesicle budding from presynaptic endocytic zone membrane; response to ethanol
Reference #:  P19357 (UniProtKB)
Alt. Names/Synonyms: Glucose transporter 4 insuline-responsive; Glucose transporter 4, insuline-responsive; Glucose transporter type 4, insulin-responsive; GLUT-4; Glut4; GTR4; MGC93607; Slc2a4; solute carrier family 2 member 4; solute carrier family 2 (facilitated glucose transporter), member 4; solute carrier family 2 , member 4; Solute carrier family 2, facilitated glucose transporter member 4
Gene Symbols: Slc2a4
Molecular weight: 54,896 Da
Basal Isoelectric point: 6.86  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling  |  Insulin Receptor Signaling  |  Warburg Effect
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene