GLUT4 Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation. Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells. Upon insulin stimulation, translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu into the cell. Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. Skeletal and cardiac muscles; brown and white fat. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of rat Ortholog: 10q24
Cellular Component:  cell surface; clathrin-coated pit; clathrin-coated vesicle; cytoplasm; cytoplasmic vesicle membrane; cytosol; endomembrane system; endosome; external side of plasma membrane; extracellular exosome; insulin-responsive compartment; integral component of membrane; integral component of plasma membrane; intracellular membrane-bounded organelle; membrane; membrane raft; multivesicular body; perinuclear region of cytoplasm; plasma membrane; presynapse; sarcolemma; sarcoplasmic reticulum; T-tubule; trans-Golgi network transport vesicle; vesicle membrane
Molecular Function:  D-glucose transmembrane transporter activity; glucose transmembrane transporter activity; protein binding
Biological Process:  amylopectin biosynthetic process; brown fat cell differentiation; cellular response to hypoxia; cellular response to insulin stimulus; cellular response to osmotic stress; cellular response to tumor necrosis factor; glucose homeostasis; glucose import; glucose import in response to insulin stimulus; glucose transmembrane transport; regulation of synaptic vesicle budding from presynaptic endocytic zone membrane; response to ethanol
Reference #:  P19357 (UniProtKB)
Alt. Names/Synonyms: Glucose transporter 4 insuline-responsive; Glucose transporter 4, insuline-responsive; Glucose transporter type 4, insulin-responsive; GLUT-4; Glut4; GTR4; MGC93607; Slc2a4; solute carrier family 2 member 4; solute carrier family 2 (facilitated glucose transporter), member 4; solute carrier family 2 , member 4; Solute carrier family 2, facilitated glucose transporter member 4
Gene Symbols: Slc2a4
Molecular weight: 54,896 Da
Basal Isoelectric point: 6.86  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling  |  Insulin Receptor Signaling  |  Warburg Effect
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene