stomatin Regulates ion channel activity and transmembrane ion transport. Regulates ASIC2 and ASIC3 channel activity. Belongs to the band 7/mec-2 family. Detected in erythrocytes (at protein level). Widely expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 9q33.2
Cellular Component:  azurophil granule membrane; cytoskeleton; endoplasmic reticulum; integral component of plasma membrane; melanosome; membrane raft; mitochondrion; perinuclear region of cytoplasm; plasma membrane; specific granule membrane; tertiary granule membrane
Molecular Function:  protein binding; protein homodimerization activity; RNA polymerase binding
Biological Process:  neutrophil degranulation; positive regulation by host of viral genome replication; positive regulation of protein targeting to membrane; protein homooligomerization; regulation of acid-sensing ion channel activity
Disease: Overhydrated Hereditary Stomatocytosis
Reference #:  P27105 (UniProtKB)
Alt. Names/Synonyms: BND7; EPB7; EPB72; Erythrocyte band 7 integral membrane protein; erythrocyte membrane protein band 7.2 (stomatin); Protein 7.2b; STOM; Stomatin
Gene Symbols: STOM
Molecular weight: 31,731 Da
Basal Isoelectric point: 7.71  Predict pI for various phosphorylation states
Select Structure to View Below

stomatin

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein