PSTPIP1 an SH3-domain containing protein that may play a role in vesicle formation and transport. Interacts with PTP-PEST to inhibit WASp-driven actin polymerization and synapse formation. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 15q24.3
Cellular Component:  cleavage furrow; cytosol; lamellipodium; perinuclear region of cytoplasm; uropod
Molecular Function:  identical protein binding; protein binding
Biological Process:  cell adhesion; endocytosis; inflammatory response; innate immune response; signal transduction
Disease: Pyogenic Sterile Arthritis, Pyoderma Gangrenosum, And Acne
Reference #:  O43586 (UniProtKB)
Alt. Names/Synonyms: CD2 antigen-binding protein 1; CD2 cytoplasmic tail-binding protein; CD2-binding protein 1; CD2BP1; CD2BP1L; CD2BP1S; H-PIP; PAPAS; PEST phosphatase-interacting protein 1; PPIP1; proline-serine-threonine phosphatase interacting protein 1; Proline-serine-threonine phosphatase-interacting protein 1; PSTPIP; PSTPIP1
Gene Symbols: PSTPIP1
Molecular weight: 47,591 Da
Basal Isoelectric point: 5.35  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene