PSTPIP1 Involved in regulation of the actin cytoskeleton. May regulate WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS and allow PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell:APC contact site so as to promote the actin polymerization required for synapse induction during T-cell activation. Down-regulates CD2-stimulated adhesion through the coupling of PTPN12 to CD2. Also has a role in innate immunity and the inflammatory response. Recruited to inflammasomes by MEFV. Induces formation of pyroptosomes, large supramolecular structures composed of oligomerized PYCARD dimers which form prior to inflammatory apoptosis. Binding to MEFV allows MEFV to bind to PYCARD and facilitates pyroptosome formation. Regulates endocytosis and cell migration in neutrophils. Highly expressed in the peripheral blood leukocytes, granulocytes and monocytes, namely in T-cells and natural killer cells, and in spleen. Weakly expressed in the thymus, small intestine, lung and placenta. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 9|9 B
Cellular Component:  actin filament; actomyosin contractile ring; cell projection; cleavage furrow; cytoplasm; cytoskeleton; membrane; plasma membrane; stress fiber
Molecular Function:  actin binding; actin filament binding; cytoskeletal protein binding; identical protein binding; protein binding; protein phosphatase binding
Biological Process:  actin filament polymerization; cell adhesion; endocytosis; immune system process; inflammatory response; innate immune response
Reference #:  P97814 (UniProtKB)
Alt. Names/Synonyms: CD2BP1; def-2; OTTMUSP00000032087; PEST phosphatase-interacting protein 1; PPIP1; Proline-serine-threonine phosphatase-interacting protein 1; Pstpip1
Gene Symbols: Pstpip1
Molecular weight: 47,590 Da
Basal Isoelectric point: 5.42  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene