nAChRA7 After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-7/CHRNA7 sub-subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Protein type: Channel, cation; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: acetylcholine-gated channel complex; axon; cytoplasm; dendrite; neuron projection; perikaryon; plasma membrane; postsynaptic membrane; synapse

Molecular Function: acetylcholine binding; acetylcholine receptor activity; acetylcholine-gated monoatomic cation-selective channel activity; amyloid-beta binding; chloride channel regulator activity; protein homodimerization activity; toxic substance binding

Biological Process: calcium ion transport; cognition; excitatory postsynaptic potential; intracellular calcium ion homeostasis; monoatomic ion transmembrane transport; negative regulation of tumor necrosis factor production; nervous system process; positive regulation of angiogenesis; positive regulation of cell population proliferation; positive regulation of MAPK cascade; regulation of membrane potential; response to hypoxia; response to nicotine; signal transduction; synaptic transmission, cholinergic

Reference #: P22770 (UniProtKB)

Alt. Names/Synonyms: cholinergic receptor nicotinic alpha 7 subunit; CHRNA7; nAChRA7; neuronal acetylcholine receptor protein, alpha-7 chain; Neuronal acetylcholine receptor subunit alpha-7

Gene Symbols: CHRNA7

Molecular weight: 56,947 Da

Basal Isoelectric point: 5.47 Predict pI for various phosphorylation states

CST Pathways: Alzheimer's Disease

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nAChRA7

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