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nAChRA7
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-7/CHRNA7 sub-subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Channel, cation; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass |
| Chromosomal Location of human Ortholog: 15q13.3 |
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Cellular Component:
acetylcholine-gated channel complex; membrane; neuron projection; plasma membrane; plasma membrane raft; postsynapse; postsynaptic membrane; synapse
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Molecular Function:
acetylcholine binding; acetylcholine receptor activity; acetylcholine-gated cation-selective channel activity; amyloid-beta binding; calcium channel activity; chloride channel regulator activity; excitatory extracellular ligand-gated ion channel activity; ion channel activity; neurotransmitter receptor activity; protein binding; protein homodimerization activity; toxic substance binding; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
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Biological Process:
acetylcholine receptor signaling pathway; calcium ion transmembrane transport; calcium ion transport; cellular calcium ion homeostasis; chemical synaptic transmission; cognition; dendrite arborization; dendritic spine organization; excitatory postsynaptic potential; ion transmembrane transport; ion transport; learning or memory; memory; modulation of excitatory postsynaptic potential; negative regulation of amyloid-beta formation; negative regulation of tumor necrosis factor production; nervous system process; positive regulation of amyloid-beta formation; positive regulation of angiogenesis; positive regulation of cell population proliferation; positive regulation of CoA-transferase activity; positive regulation of ERK1 and ERK2 cascade; positive regulation of excitatory postsynaptic potential; positive regulation of long-term synaptic potentiation; positive regulation of MAPK cascade; positive regulation of protein metabolic process; positive regulation of protein phosphorylation; regulation of amyloid fibril formation; regulation of amyloid precursor protein catabolic process; regulation of membrane potential; regulation of neuron death; response to acetylcholine; response to amyloid-beta; response to hypoxia; response to nicotine; sensory processing; short-term memory; signal transduction; synapse organization; synaptic transmission, cholinergic
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Disease: Chromosome 15q13.3 Deletion Syndrome
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Reference #:
P36544
(UniProtKB)
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Alt. Names/Synonyms: a7 nicotinic acetylcholine receptor; ACHA7; alpha 7 neuronal nicotinic acetylcholine receptor; alpha-7 nicotinic cholinergic receptor subunit; cholinergic receptor nicotinic alpha 7 subunit; cholinergic receptor, nicotinic alpha 7; cholinergic receptor, nicotinic, alpha 7; cholinergic receptor, nicotinic, alpha 7 (neuronal); cholinergic receptor, nicotinic, alpha polypeptide 7; CHRNA7; CHRNA7-2; NACHRA7; neuronal acetylcholine receptor protein, alpha-7 chain; Neuronal acetylcholine receptor subunit alpha-7
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Gene Symbols: CHRNA7
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Molecular weight:
56,449 Da
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Basal Isoelectric point:
6.02
Predict pI for various phosphorylation states
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CST Pathways:
Alzheimer's Disease
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