DYN2 Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones. Plays an important role in vesicular trafficking processes, in particular endocytosis. Involved in cytokinesis. Regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane. Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. Ubiquitously expressed. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.6.5.5; Hydrolase; Microtubule-binding; Motility/polarity/chemotaxis; Vesicle
Chromosomal Location of Human Ortholog: 9 A3|9 7.79 cM
Cellular Component:  axon; cell junction; cell projection; centrosome; clathrin-coated endocytic vesicle; clathrin-coated pit; cytoplasm; cytoplasmic vesicle; cytoskeleton; cytosol; dendritic spine; dendritic spine head; endosome; glutamatergic synapse; Golgi apparatus; Golgi membrane; lamellipodium; membrane; microtubule; nucleus; perinuclear region of cytoplasm; phagocytic cup; photoreceptor inner segment; plasma membrane; postsynaptic density; postsynaptic density, intracellular component; postsynaptic endocytic zone membrane; postsynaptic membrane; protein-containing complex; ruffle membrane; synapse; trans-Golgi network
Molecular Function:  D2 dopamine receptor binding; GTP binding; GTPase activity; hydrolase activity; microtubule binding; nitric-oxide synthase binding; nucleotide binding; phosphatidylinositol 3-kinase regulatory subunit binding; protein binding; protein kinase binding; protein-containing complex binding; SH3 domain binding; WW domain binding
Biological Process:  aorta development; cellular response to dopamine; coronary vasculature development; endocytosis; G protein-coupled receptor internalization; Golgi to plasma membrane transport; macropinocytosis; negative regulation of membrane tubulation; negative regulation of non-motile cilium assembly; negative regulation of transforming growth factor beta receptor signaling pathway; neuron projection morphogenesis; phagocytosis; positive regulation of clathrin-dependent endocytosis; positive regulation of endocytosis; positive regulation of lamellipodium assembly; positive regulation of nitric oxide biosynthetic process; positive regulation of phagocytosis; positive regulation of sodium:potassium-exchanging ATPase activity; positive regulation of substrate adhesion-dependent cell spreading; postsynaptic neurotransmitter receptor internalization; receptor internalization; receptor-mediated endocytosis; regulation of axon extension; regulation of Golgi organization; regulation of Rac protein signal transduction; regulation of synapse structure or activity; synaptic vesicle budding from presynaptic endocytic zone membrane; synaptic vesicle endocytosis; transferrin transport; ventricular septum development
Reference #:  P39054 (UniProtKB)
Alt. Names/Synonyms: Dnm2; Dyn2; dynamin 2; Dynamin UDNM; Dynamin-2
Gene Symbols: Dnm2
Molecular weight: 98,145 Da
Basal Isoelectric point: 7.02  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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DYN2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene