DYN2 Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones. Plays an important role in vesicular trafficking processes, in particular endocytosis. Involved in cytokinesis. Regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane. Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. Ubiquitously expressed. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.6.5.5; Hydrolase; Microtubule-binding; Motility/polarity/chemotaxis; Vesicle
Chromosomal Location of human Ortholog: 19p13.2
Cellular Component:  clathrin-coated pit; cytoplasm; cytosol; endocytic vesicle membrane; Golgi apparatus; Golgi membrane; growth cone; membrane; microtubule; midbody; phagocytic cup; phagocytic vesicle membrane; plasma membrane; postsynaptic density; postsynaptic membrane; presynapse; synapse
Molecular Function:  enzyme binding; GTP binding; GTPase activity; microtubule binding; protein binding; SH3 domain binding
Biological Process:  antigen processing and presentation of exogenous peptide antigen via MHC class II; endocytosis; G2/M transition of mitotic cell cycle; membrane organization; negative regulation of membrane tubulation; neuron projection morphogenesis; phagocytosis; positive regulation of apoptotic process; positive regulation of DNA-templated transcription; post-Golgi vesicle-mediated transport; receptor internalization; receptor-mediated endocytosis; regulation of axon extension; regulation of DNA-templated transcription; signal transduction; synaptic vesicle endocytosis; synaptic vesicle transport; transferrin transport
Disease: Charcot-marie-tooth Disease, Dominant Intermediate B; Lethal Congenital Contracture Syndrome 5; Myopathy, Centronuclear, 1
Reference #:  P50570 (UniProtKB)
Alt. Names/Synonyms: CMT2M; CMTDI1; CMTDIB; DI-CMTB; DNM2; DYN2; dynamin 2; dynamin II; Dynamin-2; DYNII; LCCS5
Gene Symbols: DNM2
Molecular weight: 98,064 Da
Basal Isoelectric point: 7.04  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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DYN2

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein