DYN2 Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones. Plays an important role in vesicular trafficking processes, in particular endocytosis. Involved in cytokinesis. Regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane. Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. Ubiquitously expressed. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.6.5.5; Hydrolase; Microtubule-binding; Motility/polarity/chemotaxis; Vesicle
Chromosomal Location of Human Ortholog: 19p13.2
Cellular Component:  centrosome; clathrin-coated endocytic vesicle; clathrin-coated pit; cytosol; endocytic vesicle membrane; endosome; glutamatergic synapse; Golgi apparatus; Golgi membrane; lamellipodium; microtubule; midbody; nucleus; perinuclear region of cytoplasm; phagocytic cup; phagocytic vesicle membrane; photoreceptor inner segment; plasma membrane; postsynaptic density, intracellular component; postsynaptic membrane; presynapse; protein-containing complex; ruffle membrane; trans-Golgi network
Molecular Function:  D2 dopamine receptor binding; enzyme binding; GTP binding; GTPase activity; microtubule binding; nitric-oxide synthase binding; phosphatidylinositol 3-kinase regulatory subunit binding; protein binding; protein kinase binding; protein-containing complex binding; SH3 domain binding; WW domain binding
Biological Process:  antigen processing and presentation of exogenous peptide antigen via MHC class II; aorta development; cellular response to carbon monoxide; cellular response to dopamine; cellular response to nitric oxide; cellular response to X-ray; coronary vasculature development; endocytosis; G protein-coupled receptor internalization; G2/M transition of mitotic cell cycle; Golgi to plasma membrane transport; macropinocytosis; membrane organization; negative regulation of membrane tubulation; negative regulation of non-motile cilium assembly; negative regulation of transforming growth factor beta receptor signaling pathway; neuron projection morphogenesis; phagocytosis; positive regulation of apoptotic process; positive regulation of clathrin-dependent endocytosis; positive regulation of lamellipodium assembly; positive regulation of nitric oxide biosynthetic process; positive regulation of phagocytosis; positive regulation of sodium:potassium-exchanging ATPase activity; positive regulation of substrate adhesion-dependent cell spreading; positive regulation of transcription, DNA-templated; receptor internalization; receptor-mediated endocytosis; regulation of axon extension; regulation of Golgi organization; regulation of nitric-oxide synthase activity; regulation of Rac protein signal transduction; regulation of transcription, DNA-templated; response to cocaine; response to light stimulus; signal transduction; spermatogenesis; synaptic vesicle transport; transferrin transport; ventricular septum development
Disease: Charcot-marie-tooth Disease, Dominant Intermediate B; Lethal Congenital Contracture Syndrome 5; Myopathy, Centronuclear, 1
Reference #:  P50570 (UniProtKB)
Alt. Names/Synonyms: CMT2M; CMTDI1; CMTDIB; DI-CMTB; DNM2; DYN2; dynamin 2; dynamin II; Dynamin-2; DYNII
Gene Symbols: DNM2
Molecular weight: 98,064 Da
Basal Isoelectric point: 7.04  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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DYN2

Protein Structure Not Found.


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