PAR1 High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development. Belongs to the G-protein coupled receptor 1 family. Platelets and vascular endothelial cells. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of mouse Ortholog: 13 D1|13 50.21 cM
Cellular Component:  caveola; cell surface; early endosome; integral component of membrane; integral component of plasma membrane; late endosome; membrane; neuromuscular junction; plasma membrane; platelet dense tubular network; postsynaptic membrane
Molecular Function:  G protein-coupled receptor activity; G-protein alpha-subunit binding; G-protein beta-subunit binding; heterotrimeric G-protein binding; signaling receptor binding; thrombin-activated receptor activity
Biological Process:  activation of cysteine-type endopeptidase activity involved in apoptotic process; activation of MAPKK activity; blood coagulation; cell-cell junction maintenance; connective tissue replacement involved in inflammatory response wound healing; establishment of synaptic specificity at neuromuscular junction; G protein-coupled receptor signaling pathway; hemostasis; homeostasis of number of cells within a tissue; inflammatory response; negative regulation of cell proliferation; negative regulation of glomerular filtration; negative regulation of neuron apoptotic process; negative regulation of renin secretion into blood stream; phospholipase C-activating G protein-coupled receptor signaling pathway; platelet activation; positive regulation of blood coagulation; positive regulation of calcium ion transport; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of collagen biosynthetic process; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of cytosolic calcium ion concentration; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; positive regulation of ERK1 and ERK2 cascade; positive regulation of GTPase activity; positive regulation of interleukin-6 secretion; positive regulation of interleukin-8 secretion; positive regulation of MAPK cascade; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of Rho protein signal transduction; positive regulation of smooth muscle contraction; positive regulation of transcription, DNA-templated; positive regulation of vasoconstriction; protein kinase C-activating G protein-coupled receptor signaling pathway; regulation of blood coagulation; regulation of interleukin-1 beta production; regulation of sensory perception of pain; release of sequestered calcium ion into cytosol; response to lipopolysaccharide; response to wounding; signal transduction; thrombin-activated receptor signaling pathway; trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
Reference #:  P30558 (UniProtKB)
Alt. Names/Synonyms: AI482343; Cf2; Cf2r; coagulation factor II (thrombin) receptor; F2r; MGC28086; PAR-1; Par1; Proteinase-activated receptor 1; Thrombin receptor; ThrR
Gene Symbols: F2r
Molecular weight: 47,790 Da
Basal Isoelectric point: 7.41  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene